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Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432
June 07-08, 2018
London, UK
PCOS 2018
Page 14
4th World Congress on
Polycystic Ovarian
Syndrome
M A Hasanat, J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C1-001
T he polycystic ovary syndrome (PCOS) is characterized by
hyperandrogenism, ovulatory dysfunction, and polycystic
ovarian morphologic features. PCOS affects 6 to 10% of
women of reproductive age. Marked controversy surrounds
the pathophysiology and management issues of PCOS. One
school proposes it to be a reproductive disorder while other one
considers it asanendocrinedisorder. InfactPCOS isanendocrine
disorder with adverse reproductive outcome and associated with
cardiometabolic abnormalities like impaired glucose tolerance,
type 2 DM, dyslipidemia, subclinical vascular disease and an
increased risk of cardiovascular disease. Controversies exist on
the prevalence of insulin resistance and metabolic derangement
among different PCOS phenotypes. In our studies, women with
phenotype A and B have been found to have worse metabolic
profiles and higher prevalence of cardiovascular risk factors
compared with phenotype C and D. Similarly, amenorrhoea and
oligo-amenorrhoea were found to have worst metabolic profile
and insulin resistance compared with eumenorrhoea. Although
serum antimüllerian hormone levels and prostate specific
antigen correlate with the sonographically determined antral
follicle count and ovarian volume, the diagnostic usefulness of
these in women with PCOS is uncertain. Similarly, no definitive
association could be ascertained from our studies. Biochemical
parameters of hyperandrogenemia, including total testosterone,
free androgen index and testosterone dihydrotestosterone ratio
were studied, and have been found to significantly correlate with
clinical parameters. There is controversy regarding thresholds
for diagnosis in adolescents and peri-menopausal women and
the most appropriate therapeutic approaches for these patients.
Metformin is found to have significant role in the management
as insulin resistance is the key etiopathogenic factor in PCOS,
which was also evidenced in our randomized control trial. PCOS
lies at the crossroad of metabolic and reproductive disorder and
a multi-systemic approach with involvement of the concerned
specialties is required for successful outcome.
Biography
M A Hasanat holds an MPhil and MD degree in Endocrinology and is cur-
rently working as Professor and Chairman in the Department of Endocri-
nology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka,
Bangladesh. He has more than 50 original articles published in reputed
national and international journals. His major research areas are Diabetes
(special fascination in gestational diabetes mellitus—GDM and diabetes of
young), PCOS and Infertility, Thyroid Autoimmunity and Childhood Obesity.
He is also working as an Editor (American Research Journal of Endocrinol-
ogy, International Journal of Diabetes, and Diabetes & Obesity International
Journal of different open access journals.
Polycystic ovarian syndrome—studies in
BSMMU, Bangladesh
M A Hasanat
Bangabandhu Sheikh Mujib Medical University (BSMMU), Bangladesh