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Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432
June 07-08, 2018
London, UK
PCOS 2018
Page 12
4
th
World Congress on
Polycystic Ovarian
Syndrome
G
inkgo biloba
extract is one of the most common dietary
supplements ingested by a wide cross section of the United
States population and thereforemost likely to be used by women
suffering from polycystic ovarian syndrome (PCOS). PCOS is an
ovarian disorder associated with excess androgen in women, the
cause of which includes hyperinsulinemia secondary to insulin
resistance. The major objective of our study was to determine
who might benefit from the use of
Ginkgo biloba
extract. This
presentation will discuss the results of a decade of studies in
healthy, non-diabetic and type 2 diabetic subjects, showing
that ingestions of 120 mg of
Ginkgo biloba
extract (as a single
dose) daily for three months, had the following significant
effects (p<0.05) (a) decreased collagen-mediated platelet
aggregation accompanied by reduction in urinary 11-dehydro-
TXB
2
and prostacyclin metabolites, (b) decreased platelet
in
vitro
arachidonic acid-mediated TXB
2
production, (c) reduced
platelet malondialdehyde, an index of lipid peroxidation, and (d)
increased pancreatic beta cell insulin and C-peptide production,
most significantly in type 2 diabetic subjects with pancreatic
exhaustion. In a randomized double-blind placebo-controlled
crossover study, and using a 2-step euglycemic insulin clamp
technique, it was found that ingestion of
Ginkgo biloba
extract
did not affect glucose metabolic rates at low (10 mU/m2/
min) or high (40 mU/m2/min) insulin infusion rates in healthy,
non-diabetics, those with impaired glucose tolerance or overt
type 2 diabetic subjects. Co-ingestion of Ginkgo with 500 (500
mg), a diabetes treatment which may also be prescribed for
PCOS patients, did not significantly affect the pharmacokinetic
properties of metformin. In conclusion, while all persons might
benefit from the ingestion of
Ginkgo biloba
extract, physicians
might want to caution PCOS patients about the possibility of an
increase in ovarian theca cell androgen production, even though
Ginkgo biloba
extract ingestion is unlikely to increase whole body
insulin resistance or affect metformin pharmacological activity.
Biography
George B Kudolo primarily teaches Clinical Chemistry in the Undergraduate
Clinical Laboratory Sciences Program, and Forensic Toxicology in the Grad-
uate Toxicology Program. His university is UTHealth San Antonio, USA. His
research interests are in Reproduction, Nutrition, Diabetes, Complementary
and Alternative Medicine (CAM). He has conducted clinical trials with the
herbal supplement. His other interests are the effect of herbal remedies in
general on interpretation of diagnostic laboratory tests and forensic drug
tests, and conventional drug-herb interactions.
Kudolo@uthscsa.eduGinkgo biloba extract and the PCOS
patient: Perspectives from the San Antonio
clinical trials
George B Kudolo
UT Health San Antonio, USA
George B Kudolo, J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C1-001