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E u r o p e a n C o n f e r e n c e o n
Orthopedics and
Osteoporosis
Journal of Clinical & Experimental Orthopaedics
ISSN: 2471-8416
N o v e m b e r 2 9 - 3 0 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Orthopedics and Osteoporosis 2018
Page 16
Backgroundandpurposeof thestudy:
Rheumatoidarthritis isachronicsystemicautoimmunedisease that causeschronic inflammation
of joints manifesting with swelling, pain, synovitis and joint destruction. Higher work disability rates as well as functional decline are
the causes of the knee and hip joint destruction leading to the total knee and total hip replacement surgery. Therefore, verifying the
predictive factors of aggressive disease course would manage the need for joint arthroplasty in the future
The aim of the study was to analyze the factors being approved for measuring the severity of the disease - high grade inflammation
evaluated as Das 28 (>5,1) , seropositivity, especially high titers of Anti CCP(above 500U), as well as smoking habits being proven to
indicate more intense and harsh disease progression that would lead to the joint replacement surgery (TJR) in a cohort of rheumatoid
arthritis (RA) patients .The other goal of the study was to evaluate TJR regarding to the age when RA was diagnosed and the age when
complaints started, as well as erosive joint disease, synovitis in small joints, BMI, comorbidities (primary arterial hypertension, diabetes
mellitus, stroke) in a cohort of rheumatoid arthritis patients.
Material andMethods:
A case-control prospective study was conducted with one hundred fifteen RA patients, female 80.9%, aged from
21 to 84 years. Thirteen of them had joint replacement surgery after RA was diagnosed, and they were considered as a case group. The
case and control groups were matched in age, gender and disease duration. Disease activity was measured by the Das28 score and the
CDAI score; HAQ was evaluated. High disease activity was accepted as Das 28 score>5,1, but high levels of Anti CCP titers (above 500
U) were considered as the sign of aggressive disease course more prone to erosive process and joint destruction. Disease severity was
assessed using X-ray proved erosions in the small hand and feet joints; musculoskeletal sonography was performed for the synovial
joints of hands and feet. The additional information obtained was smoking history (years), BMI (body mass index), diabetes mellitus,
stroke, primary arterial hypertension, and joint replacement surgery. A P value of less than 0.05 was used as the threshold for statistical
significance. Statistical analysis was performed by using IBM SPSS 21.0.
Do aggressive course of the disease predicts
total joint replacement surgery in patients
with rheumatoid arthritis?
Evija Stumbra Stumberga
1
,
Gaida Krumina
2
and Silva Senkane
3
1
Riga Stradins University, Internal Medicine department, Latvia
2
Riga Stradins University, Radiology department, Latvia
3
Riga Stradins University, Statistical laboratory, Latvia
Evija Stumbra Stumberga et al., J Clin Exp Orthop 2018, Volume: 4
DOI: 10.4172/2471-8416-C1-004