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Journal of Nursing and Health Studies
ISSN: 2574-2825
May 28-29, 2018
London, UK
Occupational Health 2018
Page 14
4th Edition of International Conference on
Occupational Health and
Safety
Altogether more than 5000 cases were investigated since
1989 by follow-up genotoxicology monitoring investigations,
performed among workers occupationally exposed to various
carcinogens (e.g. in oil-industry with occupational exposure to
benzene, polycyclic aromatic hydrocarbons (PAHs), bitumen,
styrene and 1-3 butadiene, heavy metals etc). More than 200
workers were followed in oil refinery plants and compared to
industrial controls, by geno- and immunotoxic biomarkers. In
our follow-up genotoxicological study the exposed groups were
monitored annually by testing chromosomal aberrations, sister-
chromatid exchanges, DNA-repair capacity measurement and
immune phenotyping of peripheral blood lymphocytes. Our
results showed the effectiveness of active prevention together
with the lowering of exposure by proper chemical safety
interventions and by changes in life style (diet, smoking, alcohol
consumption). However, besides exposures, the results were
negatively affected by medication, obesity, non-alcoholic fatty
liver and smoking. The detection of early signs of genotoxic
effects of occupational and environmental carcinogens causing
DNA-damages, mutations and chromosome aberrations, are
indicators of the increase risk for the development of cancer.
A possible attempt for prevention is the elimination of the
harmful agents from the (working) environment (primary
prevention), or promoting the elimination of somatic mutations
(chemoprevention), by changes in life style with cooperation
with local occupational health care authorities. The incidences of
malignant diseases were less among the monitored oil refinery
workers, compared to age matched controls followed by the
same methodology.
Biography
Anna Tompa completed her Graduation from Semmelweis University Fac-
ulty of Medicine as a Medical Doctor, with the specialties including Pathol-
ogy, Social and Community Medicine. Presently, she is Professor emeritus
and Vice director of Semmelweis University, Institute of Public Health, Bu-
dapest, Hungary.
Occupational cancer prevention system
among oil-refinery workers by geno-and
immuntoxicological biomarkes
Anna Tompa
Semmelweis University, Hungary
Anna Tompa, J Nurs Health Stud 2018, Volume 3
DOI: 10.21767/2574-2825-C2-004