15 / 23
Page 59
J Obes Eat Disord, 2017
ISSN: 2471-8203
August 23-24, 2017 | Toronto, Canada
allied
academies
INTERNATIONAL OBESITY, BARIATRIC AND
METABOLIC SURGERY SUMMIT AND EXPO
T
he prevalence of obesity has increased exponentially
worldwide (in 2014, 10.8% of men and 14.9% of women
were obese). Obesity is related with several health disturb
on society because it associates strongly with many diseases,
including cardiovascular disease and immunological
disorders such as rheumatoid arthritis and multiple
sclerosis. The knowledge that obesity-induced inflammation
mediates the development of insulin resistance in animal
models and humans has been raising strong support. It
was shown that immune cells in visceral adipose tissue
play a major role in the regulation of obesity-induced
inflammation. Furthermore, obesity increases the numbers
and activation of proinflammatory immune cells, including
M1 macrophages, neutrophils, Th1 CD4 T cells and CD8 T
cells, while simultaneously suppressing anti-inflammatory
cells such as CD4 regulatory T cells, regulatory B cells and
eosinophils. Recently, some studies have been made in the
attempt to understand obesity and insulin resistance linked
to immunology mediators. We focused on the roles that
these relatively new players in the metabolism field play
in obesity-induced insulin resistance and the regulation of
obesity.
e:
biafran@hotmail.comRole of inflammatory mediators in obesity-induced insulin resistance
Beatriz Dal Santo Francisco Bonamichi
Santa Casa Medical School, Brazil
J Obes Eat Disord, 3:2
DOI: 10.21767/2471-8203-C1-003