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Volume 05
Journal of Clinical Nutrition & Dietetics
ISSN: 2472-1921
JOINT EVENT
June 17-18, 2019 London, UK
Nutrition World 2019
Euro Obesity 2019
June 17-18, 2019
&
26
th
World Nutrition Congress
15
th
Euro Obesity and Endocrinology Congress
Association between omentin and chemerin levels and their changes within one year in non-morbid
overweight and obese adults
Vija Silina
1
, Mesfin K Tessma
2
, Jelena Danilenko
1
, Julija Snaidere
1
, Silva Senkane
1
and
Guntis Bahs
1
1
Riga Stradins University, Latvia
2
Karolinska Institutet, Sweden
Background:
About half of EU adult population is overweight, including 16% being obese (21% in Latvia). Early
recognition and monitoring of individuals that are at high risk of developing diabetes and cardiovascular diseases
is essential. Positive correlation of serum chemerin and negative correlation of omentin with weight, lipids and
insulin resistance indicators has been described; however, information on inter-relation between changes in these
parameters is scarce, especially in non-morbid overweight and obese adults.
Objective:
To determine the association between chemerin and omentin levels at baseline and their changes in
clinically healthy overweight and obese individuals within a year
Materials & Methods:
We used data from our randomised controlled study with 123 clinically healthy individuals
with a BMI above 25 m
2
/kg in the age group of 30 to 45: (47% men, age 36,8±4,2 years, BMI 32,0±4,3 kg/m
2
; total
cholesterol 5,4±0,9 mmol/L; HDL-cholesterol 1,4±0,3 mmol/L; fasting glucosae 5,2±0,5 mmol/L; HOMA-IR
3,1±1,7; 46% metabolically unhealthy according to metabolic syndrome definition; 32% smokers; 38% diagnosed
with liver steatosis on CT scan). All participants received a consultation for lifestyle changes to support weight loss.
All group showed slight weight and waist circumference decrease after 1 year. Biochemical parameters (lipids, fasting
glucose and insulin) and cytokines (omentin, chemerin) were assessed at baseline and after 1 year using Spearman’s
correlation test.
Results:
We found a weak positive correlation between chemerin and omentin (rs=0.295; p=0.001) at baseline,
contradicting our expectations. Multiple linear regression adjusted by age and gender retained significant relationship
between omentin and chemerin (B=0.088; 95% CI 0.033, 0.143; p=0.002). After one year there was a weak positive
correlation of omentin changes with chemerin changes (rs=0.186; p=0.042). However, multiple linear regression
adjusted by age and gender showed no association between omentin and chemerin changes.
Conclusion:
A positive rather than negative relationship between chemerin and omentin in non-morbid overweight
and obese adults imply that other factors besides anthropometric and metabolic indicators might be affecting
omentin and chemerin levels in this group.
Biography
Vija Silina is a lecturer of the Department Family Medicine of Riga Stradins university since 2011 teaching both students and residents. Her current research
includes preventing obesity related non-communicable diseases. She is working in the private practice as a family physician.
vija.silina@gmail.comVija Silina et al., J Clin Nutr Diet 2019, Volume 05