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Volume 4
Journal of Pediatric Care
ISSN: 2471-805X
Page 65
JOINT EVENT
May 07-08, 2018 Frankfurt, Germany
&
3
rd
International Conference on
Pediatrics and Pediatric Surgery
22
nd
Edition of International Conference on
Neonatology and Perinatology
Zinc/lipid/autophagy-mediated plasma membrane integrity signaling pathway is a new target for
developmental convulsive brain injury
Ni Hong
Soochow University, China
I
n pediatric clinics, about 75% of neonatal hypoxic-ischemic encephalopathy (HIE) have convulsions, and some children
develop epilepsy during adulthood. On the one hand, many of the first-line anticonvulsant drugs in the clinic can effectively
control convulsions caused by HIE. On the other hand, these drugs can also cause adverse effects such as white matter damage.
Therefore, there is an urgent need to reveal the mechanism of epileptogenesis, thus providing clues for finding new targets
for anti-epileptic treatment. Our research initially revealed that zinc (Zn) ion metabolism dyshomeostasis is involved in the
developmental seizure-induced regenerative sprouting of hippocampal mossy fibers, especially zinc transporters 1, 3 and ZIP6.
Secondly, lipid metabolism molecules and autophagy signals participate in the repair of long-term hippocampal and cortical
plasma membrane damage, as well as neurobehavioral and cognitive function protection following developmental seizures.
We have found that lipid metabolism control methods such as the ketogenic diet, leptin and melatonin, or intraperitoneal
injection of autophagy inhibitors (3-MA, CBI, E-64d) immediately after seizures, can inhibit hippocampal sprouting and
neurobehavioral damage. Our preliminary results indicate that the regulation of plasma membrane integrity mediated by zinc/
lipid/autophagy signaling may be involved in the pathophysiological process of epileptogenesis, which may be a new target for
repair of neuronal membrane damage after developmental seizures.
nyr2000@yeah.netJ Pediatr Care, Volume 4
DOI: 10.21767/2471-805X-C2-009