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Volume 4, Issue 2

American Journal of Ethnomedicine

ISSN 2348-9502

Natural Products Congress & World Pharma Congress 2017

October 16-18, 2017

World Congress on

NATURAL PRODUCTS CHEMISTRY AND RESEARCH

WORLD PHARMA CONGRESS

October 16-18, 2017 Budapest, Hungary

Anti-neuroinflammatory mechanism of 7-methoxyflavanone in lipopolysaccharide-stimulated BV2

microglia cells

Zhao Qu, Xiaoling Shen

and

Yingjie Hu

Guangzhou University of Chinese Medicine, China

icroglia plays an important role in the neurodegenerative diseases in the central nervous system. Over activated microglia

also leads to the production of excessive inflammatory molecules and deleterious consequences, including neuronal death.

7-methoxyflavanone (MF), one of the nature flavone extracted in Ixeridium gracile, has been shown to inhibit the cytochrome P450

aromatase and the MAO-B. However, its function and the underlying mechanisms in neuroinflammation responses in microglia

remain poorly understood. In this study, we investigated MF inhibited expression of COX-2 and inflammation mediators ICAM-

1 and MCP-1 in Lipopolysaccharide (LPS)-stimulated BV-2 microglia. MF also reduced the production of pro-inflammatory

cytokines (TNF-α and IL-6) induced by LPS. Furthermore, investigation of the molecular mechanism indicated that MF inhibited the

phosphorylation of ERK and JNK at a lower concentration than that for p38 MAPK. Further experiments revealed that MF treatment

considerably increased the activation of Nrf2 and the expression of its target genes, including HO-1 and NQO1. MF also induced

phosphorylation of AMPK/LKB in microglia. Interestingly, we found that MF inhibits TLR4/MyD88 signaling by interfering with

LPS and TLR4 interactions. Therefore, MF might be useful as a therapeutic agent for the treatment of neuroinflammation-associated

disorders such as Alzheimer's disease and Parkinson's disease.

Biography

Zhao Qu is a post-doctoral fellow at Guangzhou University of Chinese Medicine, China. She is expertise in natural products and medicinal chemistry.

Zhao Qu et al., American Journal of Ethnomedicine, 4:2

DOI: 10.21767/2348-9502-C1-002