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E u r o S c i C o n C o n f e r e n c e o n
Nanotechnology &
Smart Materials
Nano Research & Applications
ISSN 2471-9838
O c t o b e r 0 4 - 0 6 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Nanotechnology & Smart Materials 2018
Page 31
T
he descend of medicine to a nanometer level has led to the development of
new diagnostic and treatment strategies. Functionalized nanoscaled ma-
terials have been created to be used in the prevention and treatment of various
diseases such as neurodegenerative disorders, cancer, atherosclerosis, diabetes
and regenerative medicine, including tissue engineering and cell therapy. The inci-
dence of breast cancer is increasing in the developing world and despite advances
in cancer molecular profiling there is still no effective cure for some aggressive
primary cancers. One of the main approaches of nanotechnology against cancer
is the development of nanoparticles that deliver chemotherapy drugs directly to
tumour cells. Here we present the generation of an effective, safe and non-toxic
nanosystem for use
in vivo
with theranostic application for selective antitumor
treatment. The nanodevice was designed to efficiently conjugate therapeutics and
diagnostic cargoes based on the use of synthetic nanospheres that were multiva-
lent and tri-functionalized with: a drug; a diagnostic agent and a tumour-specific
peptide.
In vivo
evaluation of the nanodevice was conducted using an orthotopic
xenotransplant mice model injected with the breast carcinona cell line (MDA MB
231). Treatment reduced tumour size and decreased side effect associated with
Doxorubicin without any toxicity signs in treated mice
Biography
Macarena Perán has graduated with a BS in Biology and aMS in
Biochemistry andMolecular Biology in 1996 from the University
of Málaga, Spain. She moved to the Neuroscience Department
at Durham University, UK, where she was awarded with a Marie
Curie Fellowship and graduated in 2000 with a PhD. She then
completed a Postdoctoral program in the Faculty of Medicine
at Granada University. In 2005 and 2006, she was gone to Bath
University, UK, and was a short-termPostdoctoral Fellow in Prof
David Tosh lab. In 2011 she spent a year as a Visiting Scientist
in the Salk Institute for Biological Studies, California in Prof Juan
Carlos Izpisua-Belmonte lab. Actually, she is Reader in Anato-
my, University of Jaen, and Member of the Scientific Advisory
Board at Propanc Health Group Corporation. She hasmore than
50 peer-reviewed publications in international journals and has
participated in more than 20 competitive research projects and
has led 7 research contracts within the private sector.
mperan@ujaen.esNovel perspectives in nanomedicine: example
of engineered nanoparticles for breast
cancer therapy
Macarena Peran
3
, S Navarro-Marchal
1
,
V Cano-Cortes
2
, J J Díaz-Mochon
2
,
R Sanchez-Martin
2
and J A Marchal
1
1
University of Granada, Spain
2
GENYO, Parque Tecnológico de Ciencias de la Salud (PTS), Spain
3
University of Jaén, Spain
Macarena Peran et al., Nano Res Appl Volume:4
DOI: 10.21767/2471-9838-C6-024