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Nanomat 2019 Nano Research & Applications
ISSN: 2471-9838 Page 32
January 28-29, 2019
Barcelona, Spain
18th Edition of International Conference on
Emerging Trends in
Materials Science and
Nanotechnology
In thepresent study, uniformcoaxial electrospunpolycaprolactone/
silk fibroin nanofiber was prepared through adjusting the
processing parameters and shown to be a viable substrate for
antibody immobilization. Using a coaxial tube spinneret with
two different solutions, which are pumped to the inner tube
and outer tube, electrospun fibers with core-shell structures
can be fabricated. Solutions of polycaprolactone (15%) and
polycaprolactone (10%)/silk fibroin (10%) blend were individually
delivered to the inner and outer channel of a coaxial-tube
spinneret for electrospinning to prepare core-shell fibers. The
efficiciency of antibody immobilization on nanofiber was tested
by in point of care testing. Coaxial electrospun polycaprolactone/
silk fibroin nanofibers showed superior antibody attachment,
compared to polycaprolactone based nanofiber, due to relatively
higher hydrophilicity. This study of incorporation silk fibroin
with polycaprolactone has merit of preserving the excellent
biocompatibility of silk, and the fibrous three-dimensional
polycaprolactone/silk fibroin nanofiber can present enhanced
antibody immobilization potential than polycaprolactone alone.
Thus this method might open a new pathway to preparing various
functional nanofibers with enhanced bioactivity for point of care
testing material.
Biography
Tuğba Akbay has completed her PhD at Marmara University and Postdoctoral
studies at Virginia Polytechnic University, Moleculalar Biology Department. She
has a patented product for the removal of harmful substances from breast
milk. She has publishedmore than 30 papers in reputed journals and has been
serving as an editorial board member of Turkiye Klinikleri Journal of Dental
Sciences cases.
The development of coaxial electrospun
polycaprolactone/silk fibroin based nanofiber
for antibody immobilization
Tuğba Akbay, Begüm Gökmen, Ozan Özcan and Hava Dudu Taslak
Marmara University, Turkey
Tuğba Akbay et al., Nano Res Appl 2019, Volume 5
DOI: 10.21767/2471-9838-C1-031