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Volume 4
Nano Research & Applications
ISSN: 2471-9838
Page 15
August 16-18, 2018 | Dublin, Ireland
&
JOINT EVENT
12
th
Edition of International Conference on
Nanopharmaceutics and Advanced Drug Delivery
25
th
Nano Congress for Future Advancements
Nano Congress 2018
&
Nano Drug Delivery 2018
August 16-18, 2018
Bio-inspired anionic polymers as a platform for designing novel nanoscale intracellular drug delivery systems
I
t remains a major challenge to effectively deliver therapeutic agents, in particular macromolecules, through negatively
charged lipid membrane barriers. It is the most limiting step preventing successful implementation of macromolecule-based
cell modification and intracellular therapies. This is due to endosomal entrapment of macromolecules and their degradation
in lysosomes. Many researchers have used cationic delivery systems to address this challenge. However, the positive charge
could cause some issues, such as unfavorable biodistribution, rapid renal clearance and high non-specific cytotoxicity. This
presentation presents an alternative delivery strategy based on an anionic drug delivery platform. It covers our recent efforts on
design and synthesis of novel anionic, viral-peptide-mimicking, pH-responsive, metabolite-derived polymers, and evaluation of
their use in intracellular drug delivery
in vitro
and
in vivo
. Strict control over the size, structure, hydrophobicity-hydrophilicity
balance and sequence of the polymers can effectively manipulate interactions with lipid membrane, cell and tissue models. It
has been demonstrated that the biomimetic polymers can successfully traverse the extracellular matrix in three-dimensional
multicellular spheroids, and also enable efficient loading of a wide range of macromolecules into the cell interior. This can
represent a versatile delivery platform, suitable for targeted therapeutic delivery and cell therapy for treatment of various
diseases including but not limited to cancer.
Recent Publications
1. Wang S and Chen R (2017) pH-responsive, lysine-based, hyperbranched polymers mimicking endosomolytic cell-
penetrating peptides for efficient intracellular delivery. Chemistry of Materials. 29(14):5806-5815.
2. Chen S et al. (2017) Membrane-anchoring, comb-like pseudopeptides for efficient, pH-mediated membrane
destabilization and intracellular delivery. ACS Applied Materials & Interfaces. 9(9):8021-8029.
3. Chen S andChenR (2016) A virus-mimicking, endosomolytic liposomal system for efficient, pH-triggered intracellular
drug delivery. ACS Applied Materials & Interfaces. 8(34):22457-22467.
4. Zhang W et al. (2016) pH and near-infrared light dual-stimuli responsive drug delivery using DNA-conjugated gold
nanorods for effective treatment of multidrug resistant cancer cells. Journal of Controlled Release. 232:9-19.
5. Khormaee S et al. (2013) Endosomolytic anionic polymer for the cytoplasmic delivery of siRNAs in localized
in vivo
.
Advanced Functional Materials. 23(5):565-574.
Biography
Rongjun Chen obtained his MSc Degree in Materials Science from Tsinghua University (P R China) in 2003; pursued PhD Degree at Cambridge University (UK) during
the period 2003-2007, with focus on polymer drug delivery. He carried out his Postdoctoral Research at Cambridge University first on lyophilisation of pharmaceuticals and
then on manufacture of clinical-grade lentiviral vectors for gene therapy during the period October 2006 to September 2009. In May 2013, he moved to Imperial College
London as a Lecturer and is currently a Senior Lecturer since 2016. From October 2009 to April 2013, he started his independent academic career by taking a tenure-track
faculty position as the Group Leader and BHRC Senior Translational Research Fellow at the University of Leeds. His research interests focuses on biomaterials, nano-
medicine, drug delivery and cell therapy.
rongjun.chen@imperial.ac.ukRongjun Chen
Imperial College London, UK
Rongjun Chen, Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C3-013