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Der Pharmacia Sinica
ISSN: 0976-8688
Eurosc i con Conference on
Medicinal Chemistry
and Biosimilars
M a r c h 2 5 - 2 6 , 2 0 1 9
B u d a p e s t , H u n g a r y
Medicinal Chemistry & Biosimilars 2019
Background:
Oxidative stress (OS) was defined as an imbalance between the
production of reactive oxygen species (ROS) and antioxidant defences in the
cell, which leads to oxidative damage of cell and caused many disorders and
diseases.
Aims:
To identify the interactions and relationships between oxidant and
antioxidant enzymes with risk factors in patients admitted to Cardiac Care Unit
and statistically evaluated to improve the medical approach to these cases.
Materials & Methods:
Patients between (35-70) years admitted to Cardiac
care unit at Ibn Sina Hospital Educational in Ninawa Governorate, Iraq. We are
included in research. Information and risk factors as age, body mass Index,
gender, smoking, chronic diseases history, treatment, sport, length of Cardiac
care stay and educational status were recorded also compared with healthy
people age between (35-70) years. Blood samples were taken and the serum
was separated and used to estimate the following biochemical parameters:
activity of enzymes (Peroxidase, lacto peroxidase, and myeloperoxidase,
glutathione-S transfers, glutathione peroxidase, arylesterase and catalase),
also the concentration of Malondialdehyde (MDA), total lipids, total cholesterol,
triglyceride, lipoproteins and the risk factor ratio were determined by using
BIOLABO kit, also data analyzed by using statistical software package; SPSS
version, a p<0.05 is considered as significant.
Results:
The results demonstrated a significant decrease in the activity
of antioxidant enzymes (glutathione-S transfers, glutathione peroxidase,
arylesterase and catalase) in patient’s group comparison to control. The results
also showed a significant increase in the activity of oxidant enzymes (Peroxidase,
lacto peroxidase, and myeloperoxidase) in the serum of cardiovascular patients
group for both sexes in comparison with control. The results also indicated
a significant increase in the concentration of malondialdehyde (MDA), total
lipids, total cholesterol, triglyceride, Very low density lipoprotein-cholesterol
(VLDL-C), Low density lipoprotein-cholesterol (LDL-C) and the risk factor ratio
(total Cholesterol/ HDL) in serum patients . While a significant decrease in the
concentration of high density lipoprotein-cholesterol (HDL-C) in serum patients
compared with control. Correlation coefficients between oxidant and antioxidant
enzymes were examined in control and cardiovascular patients. The results
showed that there was a significant positive correlation between the activity
The correlation of oxidant and antioxidant enzymes in
cardiovascular patients in Iraq
Thikra A Allwsh
University of Mossul, Iraq
Thikra A Allwsh, Der Pharmacia Sinica 2019, Volume:10
DOI: 10.21767/0976-8688-C1-003
Biography
Thikra A Allwsh has completed her PhD fromMossul University.
She has published more than 30 papers in reputed journals and
has been serving as an Editorial Board Member of repute. She
is serving as a Professor of Biochemistry University of Mossul.
She is the Head of the Biochemistry and then supervised
many Doctoral and Master's studies. She has participated in
the discussion of a large number of students of Master's and
Doctorate and also participated in many conferences and
seminars in the field of Biochemistry as well as supervision of
the projects of undergraduate students.
Allwsh2007@yahoo.com