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Der Pharmacia Sinica
ISSN: 0976-8688
Eurosc i con Conference on
Medicinal Chemistry
and Biosimilars
M a r c h 2 5 - 2 6 , 2 0 1 9
B u d a p e s t , H u n g a r y
Medicinal Chemistry & Biosimilars 2019
Pseudoternary and nanostructured systems are important resources to
increase the solubility and transport lipophilic drugs, besides promoting
controlled release of the drug, they can still increase their time permanence
in the place of action. The work objective was to evaluate the physical
structure of the pseudoternary and nanostructured system composed of
soybean phosphatidylcholine and hydrogenated castor oil (tensoactive /
cosurfactant, 50:50 ratio), capric triglyceride (oily phase) and acetate buffer
pH 4.5 (aqueous phase) for intravaginal administration of drugs using
polarized light microscopy (PLM), X-ray diffraction (XRD), small angle x-ray
scattering (SAXS) and rheological behavior. PLM was made using polarized
light microscope with magnification of 10 and 20 times. XRD and SAXS study
evaluated the diffracted beams intensities in relation of the diffraction angles
and the rheological behavior was evaluated by continuous and oscillatory
tests using a plate/plate geometry (20 mm diameter) and rheometer at 30ºC.
The results of the PLM showed anisotropic structures that suggest crystals
and "malt of crosses" showing a mixture of crystals and lamellar liquid-
crystalline mesophase. Diffractograms presented fine and defined peaks,
which also showed crystalline structures probably from system components.
SAXS analysis presented the 1:2:3 ratio in the interplanar distances, which
sugest lamellar mesophase. The results obtained with MLP, XRD and SAXS
are complementary because the lamellar mesophase arrangements and the
presence of many crystalline structures were observed in all techniques.
Pseudoternary and nanostructured system presented non-Newtonian, anti-
thixotropic and pseudoplastic rheological behavior. Oscillatory rheological
analysis showed the predominance of the elastic behavior. These behaviors are
advantageous for intravaginal administration because at the time application
the system are fluid and after the tension applied, it was able to restructure
itself by acquiring high viscosity again and promoting greater contact with the
vaginal mucosa.
Biography
Ligia de Souza Fernandes has completed her Master's degree
from the Paulista State University "Julio de Mesquita Filho"
(Faculty of Pharmaceutical Science) and currently is a Doctoral
Student (PhD student) in the same university. Her advisor
is Maria Virginia Scarpa and their research is based on the
development of controlled release systems. She has published
one article in an internationally renowned journal. During her
Master's degree she has developed a partnership with the
University of Porto (Portugal). She has worked in national
and multinational pharmaceutical industry in R&D area and
physical-chemical quality control. CAPES fund your research
since master´s degree.
Structural physical analysis of the pseudoternary and
nanoestrutured system composed of soybean phosphtyilcoline
and hydrogenated castor oil
Ligia de Souza Fernandes1 , Anselmo Gomes de Oliveira1 ,
Marcelo Gde Freitas Araujo2 and Maria Virginia Scarpa1
1Sao Paulo State University, Brazil
2Federal University of Sao Joao Del-Rei, Brazil
Ligia de Souza Fernandes et al., Der Pharmacia Sinica 2019, Volume:10
DOI: 10.21767/0976-8688-C1-003