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Pain Management 2018
Internal Medicine 2018
International Journal of Anesthesiology & Pain Medicine
ISSN: 2471-982X
Page 82
March 26-28, 2018
Vienna, Austria
JOINT EVENT
7
t h
E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Internal Medicine and Patient Care
&
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t h
E d i t i o n o f I n t e r n a t i o n a l C o n f e r e n c e o n
Pain Management
Volume 4
C
hronic kidney disease (CKD) is a common clinical problem in
elderly patients. Serum cystatin C is protein which suggested
to be an ideal marker of glomerular filtration rate (GFR). CKD is a
risk factor for dementia. We aimed to determine the serum levels
of cystatin C in patients with CKD and to correlate this with degree
of cognitive impairment and stages of kidney disease. 90 subjects
aged 65 years and older were involved, divided into two groups;
Group I: 60 patients with CKD, and Group II: 30 with age and sex
matched healthy participants. Patients with heart failure, hepatic
failure, thyroid disease, patients underwent dialysis for longer
than one month, patients had polycystic kidney disease, who had
bonemarrow transplant, and those receiving immunosuppressive
therapy with in the past six months were excluded from the
study. Mini-Mental scale (MMS), serum cyctatin level, stage
of CKD were done to all participants. Serum cystatin level was
significantly high in CKD patients. MMS score was significantly
lower in CKD patients. A high significant negative correlation was
found between serum cystatin C levels and degree of cognitive
impairment. Also a significant positive correlation was found
between levelsof cognitive impairment andGFR. Ahighsignificant
negative correlation was found between serum cystatin C levels
and GFR (R=-0.531, p <0.001). We concluded that serum cystatin
levels are significantly associated with cognitive impairment
in CKD patients, and this correlation becomes stronger with
advanced stages of CKD. That may help in better understanding
of the pathogenesis of dementia in CKD patients.
drmarwasaad74@gmail.comStudy of the association between cognition and levels of
cystatin C in elderly patients with chronic kidney disease
Marwa A Saad, Marwa A Waly, Suzan N Abo-Raya
and
Neveen L Saad
Alexandria University, Egypt
Int J Anesth Pain Med 2018, Volume 4
DOI: 10.21767/2471-982X-C1-003