infectious-diseases-std-aids-2018-scientifictracks

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Infectious Diseases
and STD-AIDS
Infectious Diseases and STD-AIDS 2018
Journal of Transmitted Diseases and Immunity
ISSN 2471-8084
A p r i l 2 6 - 2 7 , 2 0 1 8
R o m e , I t a l y
Page 24
W e present the results of morphological studies of tuberculosis and
nonspecific inflammatory changes of the guinea pigs in the treatment of
different ratios of isoniazid with pyridoxine hydrochloride. Guinea pigs are well
suited to study airborne TB transmission due to their exceptional vulnerability
to infection with as little as a few inhaled mycobacteria. The guinea pig also
replicates many aspects of TB infection in humans, including the formation of
granulomata, primary and hematogenous pulmonary lesions, dissemination,
and caseation necrosis. The optimal dose ratio of the expression of specific and
non-specific manifestations of inflammation in the lungs and liver also prayed
to interpret the results of studies for the treatment of destructive tuberculosis
in humans. It was proposed a method of determining the optimum ratio of
doses of the most pronounced therapeutic effect and minimal side effects. The
aim of the study was to conduct morphological evaluation of lesions of internal
organs (lungs, liver) after treatment of experimental tuberculosis of guinea
pigs different ratios of doses of isoniazid and pyridoxine hydrochloride. The
optimal therapeutic effect is obtained by treating animals with experimental
tuberculosis isoniazid at a dose of 26 mg/kg of vitamin B6 and 10mg/kg body
weight of the animal, thus completely disappeared phenomenon specific
inflammation in the lungs, liver. This phenomenon also disappeared perifocal
nonspecific inflammation disappeared dystrophic and necrotic changes in the
studied organs.
Biography
Ludmila Gayova is a Professor and Head of Department of Bio-
logical and Bioorganic Chemistry Bogomolets National Medical
University, Kyiv, Ukraine. She has completed her MD from Bo-
gomolets National Medical University. She has published more
than 60 papers in academic journals like Ukrainian Pulmono-
logical Journal, Tuberculosis, Pulmonary disease, HIV infection,
ScienceReise and International Journal of Animal Science and
Technology and other.
Study of joint action isoniazid and vitamin B6 on the condition of liver
during of treatment of guiena pigs with experimental tuberculosis
Ludmila Gayova
Bogomolets National Medical University, Ukraine
Ludmila Gayova., J Transm Dis Immun 2018 Volume 2
DOI: 10.21767/2573-0320-C1-002