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Journal of Clinical Immunology and Allergy
ISSN: 2471-304X Page 24
16th EuroSciCon Conference on Immunology
March 11-12, 2019 | Amsterdam, Netherlands
Immunology 2019
B-cells play a crucial role in bacterial infections. These cells are not just
antibody producers but are also necessary to engender Th1 protective
immunity. This is achieved via a variety of mechanisms including cytokine
production and antigen presentation and with the involvement of both innate
signalling pathways and the B-cell receptor. The crosstalk between T-cells
and B-cells in turn modulates the qualitative traits of the antibody response.
The isotype profile of antibodies profoundly influences the function and
efficacy of the humoral response against bacteria and affects FcR usage
and complement activation. Future development of vaccines and delivery
systems will therefore need to consider the qualitative aspects of B-cell
immunity in relation to their function.
B-cell and antibody responses in
bacterial infections: quality or
quantity?
Pietro Mastroeni
University of Cambridge, UK
Biography
Pietro Mastroeni has received a degree in Medicine
and Surgery from the University of Messina, Italy. He
moved to the University of Cambridge, UK where he
completed his PhD before becoming a Research
Fellow at Imperial College, University of London UK.
He is currently a Reader in infection and immunity
at the University of Cambridge, UK. In 2017, he was
awarded the Higher Degree of Doctor of Science
(ScD) St Cambridge and he is a Fellow of the Royal
Society of Biology. He has published more than 120
papers in reputed journals, edited two books and
serves as an Editorial Board Member for several
international journals.
Pietro Mastroeni, J Clin Immunol Allergy 2019, Volume:5
DOI: 10.21767/2471-304X-C1-007