immunology-2019-keynote

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Journal of Clinical Immunology and Allergy
ISSN: 2471-304X Page 22
16th EuroSciCon Conference on Immunology
March 11-12, 2019 | Amsterdam, Netherlands
Immunology 2019
The main point of the sea star immunology and the ophuirid immunology
remain the discovery of the invertebrate primitive antibody (IPA), the
Ig kappa genes, with Ig sites which imply the complement system to be
initiated. Nine component genes from C1 to C9 have been updated these
last years, in sea star genome, in ophuirid one. We have discovered, an Fc
receptor gene, a Fab gene in these same invertebrate for the first time which
corroborate the presence of IPA. The transcriptomes are given. It is the first
time; we can speak of adaptative immunity, in Echinoderms, in invertebrates.
Since many years, even since a century long, the notion of antibody was out
of the speech of immunologists. To speak of that made you as an outlaw. It is
time to look with genomic studies which confirmwhich assert now evidence
that three classes of Echinoderms out of 5 possess an Ig kappa gene, a
Fc receptor gene. These classes are: the Asterids with Asterias rubens, the
Ophuirids with Ophiocomina nigra and the Crinoids with Antedon bifida.
Furthermore, these same classes present other similarities with human
genome: they share IRF2, IRF4, IRF8, IFNG genes in their genomes. As you
can see these data corroborate the high degree of evolution of Echinoderms.
But is it evolution? or evaluative creation?.
The sea stars Ophuirid’s Ig kappa gene
Michel Leclerc
University of Orléans, France
Biography
Michel Leclerc has obtained his Masters in
Biological Sciences from the University of Orleans.
He possessed a D E S in Biology and then a Doctorat
es Sciences in 1977 in this last University. Later he
collaborated with the Institut Pasteur of Paris as
a Co-Researcher for five years and then directed
the laboratory of Immunology of Invertebrates,
in the University of Orléans. He has been the first
to culture invertebrate cells in vitro and more
particularly sea star lymphocytes. In 1975, he
spoke already in a paper at the Science Academy
of France of Invertebrate antibody in a world where
this last notion was forbidden! Again he is the first
to immunize sea stars with various antigens. In the
years 1980 he published a paper at Eur J Immunol
with Francis Delmotte et al, about the isolation and
purification of antibody-like substances in the sea
star Asterias rubens. Then he started working on
Genomics: he discovered the sea star Ig kappa gene
(2014) with 2 Ig sites. It is the first time we can speak
of IAP (Invertebrate Primitive Antibody), so the Fab
gene, the Fc receptor gene, the Cr gene. Besides
the sea star innate response, he spoke of adaptive
immunity in an invertebrate for the first time. He has
170 international publications.
Michel Leclerc, J Clin Immunol Allergy 2019, Volume:5
DOI: 10.21767/2471-304X-C1-007