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Insights in Enzyme Research
ISSN: 2573-4466
E u r o S c i C o n C o n g r e s s o n
Enzymology and
Molecular Biology
A u g u s t 1 3 - 1 4 , 2 0 1 8
P a r i s , F r a n c e
Enzymology 2018
P
olymorphism in metalloproteins may lead to changes in heavy metal levels in the body. The risk factors of polymorphisms
in heavy metal concentrations, particularly mercury, may be due to several confounding factors including differences in
ethnicity of the analyzes populations, sample size and the type of the studied environment heavy metals to which population
are exposed. We study the effect of MT1A (A>G) and MT1A (C>G) polymorphisms on blood mercury level in Iranian population.
300 non exposure people to control group and 150 exposure people to case group were used. DNA extraction and PCR-RFLP
(restriction fragment length polymorphism) and DNA sequencing was done and blood mercury level was measured via atomic
absorption spectroscopy (AAS) technique by DMA-80. Blood mercury concentration in case group was higher than control group
(p value<0.001). There was no significant differences in case and control groups to the effect of MT1A (A>G) and MT1A (C>G)
polymorphism on blood mercury levels and P value were 0.69 and 0.44, 0.59 and 0.56 for case and control groups, respectively.
MT1A (A>G) and MT1A (C>G) polymorphism were not associated with increased level of mercury concentration in Iranian,
which needs further investigations. In conclusion, this study suggest that MT1A (A>G) and MT1A (C>G) polymorphisms are not
attractive susceptibility markers for high blood mercury concentration
.
drabdim@yahoo.comThe probable effect of MT1A (A>G) and MT1A (C>G)
SNPS of metallothionein gene on whole blood
mercury levels in Iranian populations
Mehdi Abdi
Valiasr Hospital, Tehran, Iran
Insights Enzyme Res 2018, Volume 2
DOI: 10.21767/2573-4466-C1-003