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Journal of Clinical and Molecular Endocrinology
ISSN: 2572-5432
August 09-10, 2018
Madrid, Spain
Endocrinology 2018
Page 30
11th International Conference on
Endocrinology and
Diabetology
During development organisms are more vulnerable to
adverse effects that occur both in the internal and external
environments, and among the latter, nutrition is a determining
factor. It has been widely demonstrated that malnutrition
or overnutrition produce long-term alterations generating
imbalances in the neurohormonal system that regulates energy
metabolism. It is known that estradiol has an inhibitory effect on
food intake and that this hormone also has organizing effects
on some neural networks during the first stages of life. Recent
experiments in rats have shown that estradiol during the first
two weeks of life exerts a modulatory function on the alterations
produced by malnutrition and overnutrition, and what is more
important, that this modulation has differential effects in males
and in females in the case of overnutrition. Specifically, a high
fat diet seems to alter mainly physiological parameters in
males, whereas in females the alterations can be detected in the
hypothalamic peptidergic system, concretely in the anorexigenic
peptide proopiomelanocortina (POMC). Taking into account the
modulatory role of estradiol in the first weeks of life, and that its
influence on food intake occurs through the same transcription
factor pathway (STAT3) through which leptin exerts its
anorexigenic actions on food intake, and also in its neurotrophic
function over hypothalamic circuits during development, it will be
of great importance to investigate the possible participation of
estradiol in the programming of the hypothalamic circuits that
regulate energy metabolism.
Biography
Paloma Collado graduated from National University of Distance Education of
Spain (UNED) in Psychology, and obtained her PhD in Psychobiology in 1990.
She is a Professor of Psychobiology at the same university since 1990. Her
research has been focused in the field of physiological psychology, and for the
last fifteen years, on the mechanisms involved in the development of the cere-
bral circuits that control food intake in rodents. She has developed this research
as Principal Investigator of different grants in collaboration with international
researchers.
Modulatory action of estradiol during
development on the effects of under and
overnutrition in male and female rats
Paloma Collado
National University of Distance Education, Madrid, Spain
Paloma Collado, J Clin Mol Endocrinol 2018, Volume 3
DOI: 10.21767/2572-5432-C2-004