chronic-diseases-2017-posters-accepted-abstracts

17 / 22

Volume 2, Issue 2 (Suppl) Chronic Obstructive Pulmonary Diseases
ISSN: 2572-5548
Page 64
conferenceseries.com
CO-ORGANIZED EVENT
August 31-September 01, 2017 Brussels, Belgium
&
International Conference on Chronic Diseases
6th International Conference on Microbial Physiology and Genomics
Control of D-glucose is determinant of renal preservation in diabetes
Anil K Mandal1,2, Linda M Hiebert3 and Harry Khamis4
1Mandal Diabetes Research Foundation, USA
2University of Florida, USA
3University of Saskatchewan, Canada
4Wright State University, USA
We previously reported that D-glucose is a strong predictor of renal function change in diabetes. This study is an expansion
of a previous study but with a longer duration. 85 diabetic patients were treated with a combination of glargine or
detemir and regular insulin for 26.3±24.6 (SD) months. Blood pressure was controlled by beta blockers, calcium channel
blockers, sympathetic inhibitors or a combination, and chlorthalidone in resistant cases. Angiotensin converting enzyme
inhibitors and receptors blockers (ACE/ARB) were excluded. Objectives were to determine if this paradigm of treatment
prevents progression of diabetic nephropathy. Fasting (F) and 2-hours postprandial (2hPP), glucose, serum creatinine (SCr)
and estimated glomerular filtration rate (eGFR); hemoglobin A1c (HbA1c); and sitting systolic and diastolic blood pressure
(SBP) were recorded for first and last visits. Mean blood pressure (MBP) and differences (d, 2hPP-F) were calculated for
glucose, Scr and eGFR. Parameters between first and last visits were compared using a paired t test adjusted for age, gender
and duration of treatment with P<0.05 considered significant. No significant differences were found between first and last
treatments for F and 2hPP glucose; F and 2hPP Scr; F and 2hPP eGFR, and; HbA1c. D-glucose, sitting SBP and MBP were
significantly lower at last compared to first visit. Combining both visits, D-glucose and HbA1c showed a direct and positive
correlation with dScr. Changes in post minus pretreatment values were significantly positively correlated between HbA1c and
FBG, 2hPPG or D-glucose. In conclusion, the current study reinforces the importance of control of D-glucose (2hPP-F) with
insulin and exclusion of ACEI/ARB in achieving renal preservation in diabetes.
Chron Obstruct Pulmon Dis 2017, 2:2
DOI: 10.21767/2572-5548-C1-003