chronic-diseases-2017-posters-accepted-abstracts

Volume 2, Issue 2 (Suppl)

Chronic Obstructive Pulmonary Diseases

ISSN: 2572-5548

Page 62

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CO-ORGANIZED EVENT

August 31-September 01, 2017 Brussels, Belgium

International Conference on

Chronic Diseases

International Conference on

Microbial Physiology and Genomics

Anti-obesity and hypolipidemic effects of

Cynometra cauliflora

in animal model of obesity

Atefehalsadat Seyedan, Mohammed Abdullah Alshawsh

and

Zahurin Mohamed

University of Malaya, Malaysia

ynometra cauliflora

is a medicinal plant, belonging to Fabaceae family, traditionally used to treat hyperlipidemia and

diabetes. This study investigated the anti-obesity and lipid lowering effects of ethanol extract of

C. cauliflora

leaves (200

and 400 mg/kg) and its major compound (vitexin, 10 mg/kg) on obese mice (C57BL/6) induced by high-fat diet (HFD).

Animals were fed with either a standard pellet diet for normal control group or HFD for eight weeks to induce obesity. The

oral administration of

C. cauliflora

, for eight weeks, resulted in a significant decrease in body weight gain in mice fed a high-

fat diet. Moreover, the oral administration of

C. cauliflora

resulted in a significant reduction of serum triglycerides, total

cholesterol, and low-density lipoprotein cholesterol (LDL) levels compared to the HFD control group. Besides, the

C. cauliflora

extract treatment elicited a significant reduction in serum levels of glucose and insulin compared to the HFD control group. In

addition, histology examination showed that accumulation of hepatic lipid droplets induced by HFD was reduced markedly by

C. cauliflora

. The present study thus concludes that

C. cauliflora

possess hypolipidemic activity that protects the body against

adverse effects of high fat diet-induced obesity, possibly through lipid lowering action and improving the insulin sensitivity.

Besides, these findings support traditional knowledge and suggest that

C. cauliflora

may potentially be useful for managing

obesity and hyperlipidemia.

Chron Obstruct Pulmon Dis 2017, 2:2

DOI: 10.21767/2572-5548-C1-003