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Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
August 27-28, 2018
Zurich, Switzerland
Chemistry Education 2018
Page 33
8th Edition of International Conference on
Chemistry Education
and Research
Role of polymers is substantial in delivering protein drugs.
Delivery of proteins; however, is challenging due to complex
interactions including hydrophobic interaction, electrostatic
interaction, hydrogen bonding and interaction between adsorbed
protein molecules which may lead to loss of protein stability.
Several factors that affect these interactions include polymer
type, surface charge, pH and ionic strength of the solvent
system, presence of competing proteins. It is critical to attain
mechanistic understanding of adsorption of proteins at solid/
liquid interfaces to deliver the protein in safe and effective form
at the site of action. Use of different polymers intended for
drug delivery and analytical techniques such as dynamic light
scattering spectroscopy, fluorescence spectroscopy and circular
dichroismspectroscopy isdemonstrated toscreen the factors for
development of stable dosage form. Evaluation of the changes in
secondary and tertiary structure of recombinant human growth
hormone (r-hGH) upon adsorption at biodegradablePoly (lactide-
co-glycolide) PLGA nanoparticles of different hydrophobicity
as a function of pH is illustrated to understand the nature of
the interactions that govern the adsorption of the protein on
the polymer, leading to successful design of sustained delivery
systems.
Biography
Dr Vaishnavi Parikh has completed her PhD in Pharmaceutics from Philadel-
phia College of Pharmacy, University of Sciences. She has more than eight
years of experience working as a Formulation Scientist in the pharmaceutical
industry and currently works as a Manager of Product development at Genus
Lifesciences Inc. She has published several papers in reputed journals; present-
ed at several international conferences; has been serving as a reviewer on six
reputed journals and also an editor for the journal, Insight- Automatic Control.
Polymer- protein interface and high
throughput screening for protein structural
stability
Vaishnavi Parikh
University of the Sciences in Philadelphia, USA
Genuslifesciences, USA
Vaishnavi Parikh, J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C5-013