chemistry-2019-posters-abstracts

Page 51

Journal of Organic & Inorganic Chemistry

ISSN 2472-1123

n d

E d i t i o n o f E u r o S c i C o n C o n f e r e n c e o n

Chemistry

F e b r u a r y 1 9 - 2 0 , 2 0 1 9

P r a g u e , C z e c h R e p u b l i c

Chemistry 2019

lthough naphthalene can be considered as the simplest compound from the group of arenes, it is one of the most interesting

arenes. Naphthalene-based drugs include not only clinically used anti-infective chemotherapeutics, but also other agents

with significant antimicrobial properties. The naphthalene scaffold can be found in several other therapeutic classes such as

antidepressants, nonsteroidal anti-inflammatory drugs, α1-adrenomimetrics, α1-adrenolytics, β1-adrenolytics and peroral anti-

diabetics. Thus, it can be stated that this scaffold can be considered as a privileged structure. The naphthalene scaffold can be

easily and rapidly functionalized, which provides a possibility of a great number of targeted modifications as well as modification/

optimization of physicochemical properties. This contribution is focused especially on the investigation of ring-substituted

hydroxyl naphthalene carboxamide derivatives that expressed promising biological activities as antibacterial agents against a

number of human pathogens. Structure-activity relationships and the supposed mechanism of action are discussed.

Antibacterial naphthalene-based agents

Josef Jampilek

Comenius University, Slovakia

J Org Inorg Chem 2019, Volume: 5

DOI: 10.21767/2472-1123-C1-021