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Journal of Organic & Inorganic Chemistry
ISSN 2472-1123
2
n d
E d i t i o n o f E u r o S c i C o n C o n f e r e n c e o n
Chemistry
F e b r u a r y 1 9 - 2 0 , 2 0 1 9
P r a g u e , C z e c h R e p u b l i c
Chemistry 2019
A
t present, the advantages of surfactant micelles as vehicle are taken into consideration and the impact of potential
antimicrobial drug (levofloxacin) on micellar system of anionic surfactant (SDS) has been studied. It would therefore be
interesting to evaluate the region of micelle formation in order to design such systemwhich could prove valuable in pharmaceutical
formulations. In this context, conductance study, critical micelle concentration (CMC), standard thermodynamic parameters of
micellization namely, ∆H
o
m,
∆G
o
m,
and ∆S
o
m,
have been evaluated at four different temperatures (298.15 to 313.15) K. Molar
volume and compressibility measurements have also been carried out to evaluate the apparent molar volume and apparent molar
adiabatic compression of drug-surfactant complex and discussed in terms of the solute-solute and solute-solvent interactions. In
addition, spectroscopic analysis (FTIR and
1
H–NMR) confirmed the presence of intermolecular interaction between levofloxacin-
SDS moiety within studied concentration. Conclusively, this study provides an indication to assess and develop surfactant
immobilized levofloxacin for better biological action.
kundanvashisht@gmail.comDrug surfactant interaction: thermo-acoustic
investigation of sodium dodecyl sulfate and
antimicrobial drug (Levofloxacin) for potential
pharmaceutical application
Kundan Sharma
1
, S Chauhan
2
and Bhanu Priya
2
1
Govt College Paonta Sahib-Himachal Pradesh University Shimla, India
2
Himachal Pradesh University Shimla, India
J Org Inorg Chem 2019, Volume: 5
DOI: 10.21767/2472-1123-C1-021