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E u r o S c i C o n C o n f e r e n c e o n
Chemistry
2018
Chemistry 2018
Journal of Organic & Inorganic Chemistry
ISSN 2472-1123
F e b r u a r y 1 9 - 2 0 , 2 0 1 8
P a r i s , F r a n c e
Page 73
S
ynthetic glycoclusters and glycodendrimers have
stimulated increasing interests over the past decade.
Amongthelargevarietyofmultivalentscaffoldsreportedsofar,
our group is focusing on cyclopeptide-based glycoconjugates
for diverse biological applications. In this context, well-
defined structures with various size, sugar density and
combination have been prepared using either single or
orthogonal chemoselective procedures (i.e. oxime ligation,
Huisgen 1, 3-dipolar cycloaddition, thiol-ene coupling, thiol-
chloroacetyl coupling). Here, we will present the synthesis
of several homo- and heterovalent glycocyclopeptides and
their biological properties as nanomolar lectin ligands and
antitumoral vaccines.`
olivier.renaudet@univ-grenoble-alpes.frChemoselective
synthesis of homo-
and heterovalent
glycocyclopeptides
Olivier Renaudet
University of Grenoble Alpes, France
J Org Inorg Chem 2018, Volume: 4
DOI: 10.21767/2472-1123-C1-003