21 / 44
Volume 4
Nano Research & Applications
ISSN: 2471-9838
Notes:
JOINT EVENT
October 04-05, 2018 Moscow, Russia
&
2
nd
Edition of International Conference on
26
th
International Conference on
Advanced Nanotechnology
Materials Technology and Manufacturing Innovations
Advanced Nanotechnology 2018
& Materials-Manufacturing 2018
October 04-05, 2018
Page 51
Anna Antsiferova
National Research Center ‘Kurchatov Institute’, Russia
Anna Antsiferova, Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C5-020
Accumulation of silver nanoparticles in mammalian brain and effects on cognitive functions
A
silver has been known as an antiseptic agent from the ancient times. Nowadays due to the development of the
nano technologies, silver is mostly used in nanoform and is applied in food and light industries, medicine and
pharmaceutics.Themost ambiguous area of its application is the alternativemedicine, where nanosilver is recommended
for daily use in order to treat bacterial and viral diseases and to strengthen the immunity. However, the supposed doses
are quite high and the periods of the administration are quite long. The objective of the research was to identify negative
effects caused by nano silver treatment on cognitive, behavioral and physiological functions of mammals as well as to
measure the amount of silver in the brain and their parts. Colloidal solution of PVP coated silver performed by the
food supplement Argovit C manufactured in Russia was used as silver nanoparticles. Due to Dynamic Light Scattering
(DLS) and TEM the mean size of the nanoparticles was 34±4 nm. C57BL/6 mice were used as a mammal model. The
mice have been daily exposed to the nano particles during 30, 60, 120 and 180 days in the amount of 50 µg per day. Mice
were tested in several behavioral and cognitive mazes and in Pheno Master to check their physiological functions. After
that mice were decapitated and their brain and the parts were investigated by neutron activation analysis to measure the
amount of silver in them. It can be concluded that accumulation of nanosilver in mammalian brain leads to cognitive
and behavioral impairments.
Biography
Anna Antsiferova has completed her Graduation from the Physical Faculty of Lomonosov Moscow State University in 2011. She has recieved her PhD
degree in Physics and Math at the National Research Center Kurchatov Institute in 2016. She is a Head of the Laboratory of Nanosafety of the National
Research Center Kurchatov Institute; Deputy Dean and an Assocciate Professor in the Department of Nano, Bio, Informational, Cognitive and Socio-hu-
manitarian Technologies -Moscow Institute of Physics and Technology. She has published 18 papers in reputed journals, two books and given more than 30
talks on the international conferences.
antsiferova_aa@nrcki.ru