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Page 66
Volume 4
December 10-12, 2018
Rome, Italy
Nano Research & Applications
ISSN: 2471-9838
Advanced Materials 2018
Nano Engineering 2018
JOINT EVENT
22
nd
International Conference on
Advanced Materials
and Simulation
&
22
nd
Edition of International Conference on
Nano Engineering &
Technology
I
n spite of rapidly growing peptide and protein drugs in the
market, their limited therapeutic applications are due to the
undesirable interaction between protein and solid surface. Several
developments have occurred in the field of sustained delivery of
proteins utilizing both biodegradable and non-biodegradable
polymer. However, proteins are highly susceptible to adsorption
on hydrophobic surfaces during manufacturing process which
may lead to change in structure of the protein affecting safety
and efficacy of the drug. Therefore, selecting the polymer
surface suitable for specific protein delivery by investigating
the adsorption behavior is crucial. Modified nanoprecipitation
methods was developed for nanoparticle fabrication and
equilibrium dialysis followed by fluorescence spectroscopy was
employed for quantitative characterization of the adsorption of
recombinant human growth hormone (r-hGH) onto Poly (lactic-
co-glycolic) acid (PLGA) polymers with a different degree of
hydrophobicity under varying conditions of pH. With the benefit of
large surface area of nanoparticles to study surface interactions,
internal fluorescence and circular dichroism spectroscopy were
utilized in order to characterize the physicochemical interactions
that govern the adsorption process onto polymer nanoparticles.
In addition, desorption of adsorbed r-hGH upon dilution was also
studied. The study resulted in selection of PLGA grade that can
prove to be suitable for sustained delivery of r-hGH.
Biography
Vaishnavi Parikh has completed her PhD in Pharmaceutics from
Philadelphia College of Pharmacy, University of the Sciences. She has more
than eight years of experience in working as a Formulation Scientist in the
pharmaceutical industry and currently manages Product Development
Department at Genus Lifesciences Inc. She has published several papers
in reputed journals; presented at several international conferences; has
been serving as a reviewer on six reputed journals and also an Editor for the
journal,
Insight- Automatic Control.
vrshah1987@gmail.comVaishnavi Parikh
1, 2
1
University of the Sciences, USA
2
Genus Lifesciences, USA
Vaishnavi Parikh, Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C7-028
Biodegradable polymer and nanotechnology in
protein delivery