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M a y 0 9 - 1 0 , 2 0 1 9
S t o c k h o l m , S w e d e n
Page 27 Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123 Advanced Chemistry 2019
2nd European Congress on
Advanced Chemistry
series of novel 5-methoxy-5,6-dihydro-4H-benzo[f][1,2,4]triazolo[4,3-a]aze-
pine derivatives were synthesized from 3,4-dihydronaphthalen-1(2H)-one.
The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR,
MASS spectra and elemental analysis. Their anticonvulsant activity was evalu-
ated by the maximal electroshock (MES) test, subcutaneous pentylenetetrazol
(scPTZ) test, and their neurotoxicity was evaluated by the rotarod neurotoxicity
test. The results of these tests showed that compound 4-hydroxyl-1, 3, 4, 5-tet-
rahydro-2H-1-benzazepin-2-one had moderate anticonvulsant activities, with
median effective dose (ED50) of 44.0 mg/kg, and protective index (PI) value
of 6.4 in the MES test. However, this compound did not show anticonvulsant
activity at the 100 mg/kg dose level in the scPTZ test. The level of competition
between the elimination reaction and nucleophilic substitution reaction was
discussed.
Biography
Feng-yu Piao, Yanbian University Professor, She has published
more than 12 papers in reputed journals.
Synthesis and anticonvulsant activity of 5-methoxy-5,
6-dihydro-4H-benzo[f] [1, 2, 4] triazolo [4,3-a] azepine
derivatives
Feng-yu Piao1,2, Rui-xue Chen1 and Rong-bi Han1,2
1Yanbian University Yanji, Republic of China
2Key Laboratory of Natural Resources of Changbai Mountain and Functional Molecules-YBU,
Republic of China
Feng-yu Piao et al., J Org Inorg Chem 2019, Volume:5
DOI: 10.21767/2472-1123-C2-023