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M a y 0 9 - 1 0 , 2 0 1 9
S t o c k h o l m , S w e d e n
Page 25 Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123 Advanced Chemistry 2019
2nd European Congress on
Advanced Chemistry
Alzheimer’s disease (AD), as the most common progressive
neurodegenerative disorder, is pathologically characterized by deposition
of extracellular plaque composed of amyloid-β peptide (Aβ). Therefore, the
development of reliable assays for Aβ (both monomers and oligomers) are
important for the early differential diagnosis of dementia, predicting the
progression of AD, as well as monitoring the effectiveness of novel anti-Aβ
drugs for AD. Recently, our group has constructed several analytical assays for
sensing Aβ (both monomers and oligomers): by using aptamer- and thionine-
modified gold nanoparticles (aptamer-Au-Th) as the signing probe, we
fabricated an antibody-aptamer sandwich assay for electrochemical evaluation
of levels of β-amyloid oligomers; based on metal–organic frameworks as
electrochemical signal probes, we developed a sensitive aptasensor for the
detection of β-amyloid oligomers; based on the target-mediate aggreation of
gold nanoparticle, we constructed a sensitive colorimetric assay for β-amyloid
oligomers; based on the specific binding between Cu2+ and Aβ1−40, we proposed
a colorimetric assay as well as a fluorescent assay for Aβ1−40 monomer.
Biography
Yanli Zhou has completed her PhD at the age of 27 years from
the Technical Institute of Physics and Chemistry, Chinese
Academy of Sciences. She is currently a professor at Shangqiu
Normal University. She has published more than 40 papers in
reputed journals.
Advances in determination of Alzheimer’s β-amyloid peptide
Yanli Zhou, Yuanqiang Hao, Xiuhua Wei and Maotian Xu
College of Chemistry and Chemical Engineering- Shangqiu Normal University, China
Yanli Zhou et al., J Org Inorg Chem 2019, Volume:5
DOI: 10.21767/2472-1123-C2-023