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E u r o p e a n C o n g r e s s o n
Advanced Chemistry
Advanced Chemistry 2018
J u l y 1 2 - 1 3 , 2 0 1 8
P a r i s , F r a n c e
Page 49
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
N
ew aryl substituted cyclohepta[b]pyridine and cyclohepta[d]pyrimidine derivatives were synthesized. The sugar hydrazones
of both synthesized pyridine and pyrimidine were also prepared. In addition, the 1, 3, 4-oxadiazolyl acyclo C-nucleoside
analogs of the pyridine system were synthesized. The anticancer and antimicrobial activities of some of the prepared
compounds were studied. Two compounds showed high activity against MCF-7, HEPG-2, and HCT-116 cell lines. The predicted
binding patterns of the three of the prepared compounds as possible antagonists against ERα were investigated.
Dr.Ibrahim.nassar@sedu.asu.edu ibrahimnassar72@yahoo.com ibrahimnassar72@hotmail.comDesign, synthesis, anticancer and antimicrobial
activity of new cyclohepta[b]pyridine and
cyclohepta[d]pyrimidine sugar hydrazones and
oxadiazolyl acyclic C-nucleoside analogs
Ibrahim F Nassar
1
, Wael A El-Sayed
2
and Tamer M Saleh
2
1
Ain Shams University, Cairo, Egypt
2
National Research Centre, Egypt
J Org Inorg Chem 2018, Volume: 4
DOI: 10.21767/2472-1123-C2-006