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E u r o p e a n C o n g r e s s o n
Advanced Chemistry
Advanced Chemistry 2018
J u l y 1 2 - 1 3 , 2 0 1 8
P a r i s , F r a n c e
Page 44
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
T
he prerequisite for bioinspired synthesis is the knowledge of targeted specific families of natural substances within
phylogenetically related organisms. Isolation and structural determination of secondarymetabolites of a targetedmetabolome
from marine invertebrates can give some important clues toward biogenetic chemical pathways of complex molecules. Thus,
the line of systematic tracking of structurally or chemically related metabolites is of great interest not only for the discovery
of new bioactive molecules, but also for biomechanistic and biosynthetic investigation. Pyrrole-2-imidazole (P-2-AI) alkaloids
isolated from marine sponges exhibit intriguing molecular diversity and various biological activities. Monomeric and dimeric
P-2-AI members were isolated from Axinellidae and Agelasidae families of sponges in our group (Figure 1). These compounds
have clearly emerged as promising synthetic targets and biologically active compounds. Synthetic aspects focusing either the
challenging structures or chemical libraries preparation through easy routes will be presented.
ali.almourabit@cnrs.frMarine secondary metabolites, isolation,
synthesis and bioactivity
A Al-Mourabit
CNRS-ICSN, Gif sur Yvett, France
J Org Inorg Chem 2018, Volume: 4
DOI: 10.21767/2472-1123-C2-006
Figure 1:
examples of isolated monomeric and dimeric P-2-AI metabolites