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Preventive Medicine 2018
Journal of Preventive Medicine
ISSN: 2572-5483
Page 45
July 16-17, 2018
London, UK
9
th
Edition of International Conference on
Preventive Medicine
& Public Health
E
nteric fever is caused by gram negative bacilli
Salmonella
typhi and paratyphi
. It is associated with high morbidity and
mortality worldwide. Timely initiation of treatment is a crucial
step for prevention of any complications. Cultures of body fluids
are diagnostic, but not always conclusive or practically feasible in
most centers.Moreover, the resultsof culturesdelay the treatment
initiation. Serological tests lack diagnostic value. The blood
counts can offer a promising option in diagnosis. A retrospective
study to find out the relevance of leucopenia and eosinopenia
was conducted on 203 culture proven enteric fever patients and
159 culture proven non-enteric fever patients in a tertiary care
hospital in New Delhi. The patient details were retrieved from
the electronic medical records section of the hospital. Absolute
eosinopenia was considered as absolute eosinophil count (AEC)
of less than 40 /mm
3
(normal level: 40-400/mm
3
) using LH-
750 Beckman Coulter Automated machine. Leucopoenia was
defined as total leucocyte count (TLC) of less than 4x10
9
/l. Blood
cultures were done using BacT/ALERT FA plus automated blood
culture system before first antibiotic dose was given. Case and
control groups were compared using Pearson Chi square test.
It was observed that absolute eosinophil count (AEC) of 0-19 /
mm
3
was a significant finding (p<0.001) in enteric fever patients,
whereas leucopenia was not a significant finding (p=0.096).
Using receiving operating characteristic (ROC) curves, it was
observed that patients with both AEC<14/mm
3
and TCL <8x10
9
/l had 95.6% chance of being diagnosed as enteric fever and only
4.4% had chance of being diagnosed as non-enteric fever. This
result was highly significant with p<0.001. This is a very useful
association of AEC and TLC found in enteric fever patients of this
study which can be used for the early initiation of treatment in
clinically suspected enteric fever patients.
Biography
Swati Kapoor is a second year postgraduate student in internal medicine
in New Delhi, India. She did her mbbs from lady hardinge medical college,
NewDelhi. She have keen interest in research and have participated inmany
competitions including ACP India chapter (won 2nd prize in poster compe-
tition)
.
swatikapoor3012@gmail.comAbsolute eosinopenia as a early diagnostic marker for
enteric fever
Swati Kapoor
1
, Rajeev Upreti, Monica Mahajan, Abhaya Indrayan
and
Dinesh
Srivastava
1
Max Superspeciality Hospital, New Delhi, India
Swati Kapoor et al., J Prev Med 2018, Volume 3
DOI: 10.21767/2572-5483-C1-002