9 / 12
Page 27
E u r o s c i c o n C o n f e r e n c e o n
Physical Chemistry and
Analytical Separation Techniques
October 08-09 , 2018
Amsterdam, Nether l ands
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
Physical Chemistry and Analytical Separation Techniques 2018
F
our new pyran-based cembranoidal diterpenes were isolated from the Red
Sea soft-bodied coral
Sarcophyton glaucum
. Sarcoglauphine A (1) and B
(2) are conformers with respect to the dihedral angle between H-7 and the
pair of H-6a, 6b, while sarcotrocheliol-B acetate (3) and sarcotrochelione (4)
are bicyclic cembranoids. The chemical structures of the isolated compounds
were elucidated using spectroscopic methods. The cytotoxicity of the isolated
compounds was evaluated against HepG2, MCF-7 and HCT116 cell lines by
employing Sulphorhodamine B (SRB) method. Compounds 1 and 2 showed
significant activities toward HCT116
Biography
ZahraA Alsaihati has completed her Master of Sciences in
Chemistry from King Abdulaziz University at Saudi Arabia.
She holds BSc in Biochemistry from King Abdulaziz University.
She was awarded a second prize for the best poster in the
4
th
international conference and exhibition on Laboratory
Technology Conference, which was held in Kingdomof Bahrain.
Her research interests include organic analytical separation
techniques.
Zahraa.alsaihati@gmail.comCytotoxic pyran based cembranoids from Sarcophyton glaucum
Zahra A Alsaihati
1
, Walied M Alarif
1
, Mohamed H PH
1
, Ahmed
Abdel Lateff
1,2
, Mahmoud A Elfaky
2
, Nahed O Bawakid
1
,
Najla A Alburae
1
and Hajer S Alorfi
1
1
King Abdulaziz Universit, Saudi Arabia
2
Minia University, Egypt
Zahra A Alsaihati et al., J Org Inorg Chem 2018 Volume: 4
DOI: 10.21767/2472-1123-C6-017
Figure 1:
Compounds isolated from
Sarcophyton glaucum