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Journal of Pediatric Care
ISSN: 2471-805X
March 26-27, 2018
Edinburgh, Scotland
Pediatrics Conference 2018
Page 12
2 nd Edition of International Congress on
Pediatrics
Heart failure (HF) in children is a serious public health concern.
HFhasnumerousetiologies, but unspecificsymptoms.There
is interplay among neurohumoral, and molecular abnormalities.
Major advances in chronic heart failure (cHF) therapy have
been achieved in adult patients, while research regarding the
mechanisms and therapy of chronic heart failure in children has
lagged behind. However in any case, the current chronic therapy
of systolic HF focused on loop-diuretics, fluid restriction and
digoxin as well as the definition of end-stage HF is inacceptable;
not at least in context of the potentials of regeneration reciprocal
to the patient’s age. Therefore, therapy has to extend to selective
ß1-blocker, tissue ACE-I and mineralocorticoid blockers,
and loop-diuretics avoided as ever possible. The efficacy of
endogenous neurohumoral inhibition can easily monitored,
even by parents only looking at surrogate parameters as heart
and breath rate as well as systolic and diastolic blood pressure.
Echocardiographic control of cardiac function has to include
synchrony and parameters of ventriculo-ventricular interaction
(VVI). Optimizing the left ventricular preload is advocated as an
important part of a regenerative strategy. Interventional aspects
of such a regenerative favored HF therapy include creation of
a restrictive interatrial communication, placing a reversible
pulmonary artery banding and stem cells replacement.
Biography
Dietmar Schranz, MD was a Resident and Fellow in Pediatrics, Neonatol-
ogy, Pediatric Intensive Care & Cardiology with follow-up position as As-
sistant Professor (PhD) in Pediatric Cardiology and Intensive Care at the
Gutenberg University Clinic Mainz, Germany. During 1996-2017 he was a
University Professor (C4), Justus-Liebig University Giessen, Germany, Chair
of the Department of Pediatric Cardiology, PediatricHeart Center, JLU-Gies-
sen (Germany). Since 2017 he is a Consultant in University Clinic Frankfurt
&Wuxi, China. He has publications of more than 200 peer-reviewed papers
in reputed journals and more than 100 invited talks world-wide. He has
membership inmultiple German & European societies and he is a Reviewer
of Lancet, Circulation and many other high-ranked Journals.
Heart failure in young children: regeneration
instead transplantation
Dietmar Schranz
Johann-Wolfgang Goethe University, Germany
Dietmar Schranz, J Pediatr Care, Volume 4
DOI: 10.21767/2471-805X-C1-004