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E u r o S c i C o n C o n f e r e n c e o n
PEDIATRICS
2017
Pediatrics 2017
Volume:3 Issue:4(Suppl)
Journal of Pediatric Care
ISSN 2471-805X
N o v e m b e r 1 3 - 1 4 , 2 0 1 7
L o n d o n , U K
Page 47
Introduction:
There is increasing evidence that favor the
prenatal beginning of schizophrenia. These evidences
point toward intra-uterine environmental factors that act
specifically during the second pregnancy trimester producing
a direct damage of the brain of the fetus. The current available
technology doesn’t allow observing what is happening at
cellular level since the human brain is not exposed to a direct
analysis in that stage of the life in subjects at high risk of
developing schizophrenia.
Methods:
In 1977, we began a direct electron microscopic
research of the brain of fetuses at high risk fromschizophrenic
mothers in order to find differences at cellular level in relation
to controls.
Results:
In these studies we have observed within the nuclei
of neurons the presence of complete and incomplete viral
particles that reacted in positive form with antibodies to
herpes simplex hominis type I [HSV1] virus, and mitochondria
alterations.
Direct evidence
of viral infection
and mitochondrial
alterations in the
brain of fetuses
at high risk for
schizophrenia
Segundo Mesa Castillo
Psychiatric Hospital of Havana, Cuba
J Pediatr Care 2017, 3:4(Suppl)
DOI: 10.21767/2471-805X-C1-003
Conclusion:
The importance of these findings can have
practical applications in the prevention of the illness keeping
in mind its direct relation to the aetiology and physiopathology
of schizophrenia. A study of amniotic fluid cells in women
at risk of having a schizophrenic offspring is considered. Of
being observed the same alterations that those observed
previously in the cells of the brain of the studied foetuses, it
would intend to these women in risk of having a schizophrenia
descendant, previous information of the results, the voluntary
medical interruption of the pregnancy or an early anti HSV1
viral treatment as preventive measure of the later development
of the illness
segundo@infomed.sld.cu