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Pain Management 2019 & Internal Medicine 2019 International Journal of Anesthesiology & Pain Medicine
ISSN: 2471-982X Page 31
JOINT EVENT
7th Edition of International Conference on
Pain Management
8th Edition of International Conference on
Internal Medicine &
Patient Care
&
March 25-26, 2019
Rome, Italy
Endocrine aspects of obesity in men: New links and
consequences
Nevena Ilic¹, Corrado Pasquali², Angelina Stevanovic¹, Violeta Culafic Vojinovic²,
Tatjana Eror¹ and Sasa Ivanovic¹
1Euromedik General Hospital, Serbia
2Sant’ Eugenio Hospital, Italy
Epidemiological studies in last ten years have shown
that 30-50% of obese men have lower testosterone
levels for age. Pathophysiological mechanisms of so
called dysmetabolic hypogonadismare complex and they
involve cytokine (TNF , IL 1, IL 6) and adpokine (leptin)
secretion, insulin resistance, abnormal turnover of many
hormones due to an endocrine axis changes (GNRH-
LH-testosterone, GH-IGF-1, TSH-T4,T3, ACTH-cortisol)
and obstructive sleep apnea with disturbed REM sleep
phase. Low testosterone level causes body composition
changes with higher total body fat percentage and loss of
muscle mass. High body fat worsens insulin resistance
which increases weight gain and obesity, creating a
vicious cycle. Consequences of low testosterone level in
obese men are higher risk of type 2 diabetes, metabolic
syndrome and cardiovascular diseases, cancer, infertility,
erectile dysfunction, bone loss, bone marrow changes
depression, alzheimer’s disease and higher overall
mortality. The dilemma is weather to treat these patients
with hormone replace therapy or not. Recent studies have
shown positive results in metabolic response such as
better lipid status and increased insulin sensitivity, weight
loss and body composition changes with a decrease of
fat mass and increase of musclemass in patients treated
with testosterone replacement therapy. Further studies
are required to prove if this kind of treatment decreases
mortality risk.
Biography
Nevena Ilic has completed her Sub Specialization in Endocri-
nology at Belgrade UniversityMedical School in 2009 andMas-
ter’s Degree in Thyroid Diseases in Italy 2014. She completed
Internal Medicine Specialization at Military Medical Academy
Hospital, Belgrade in 2002. Since, 2014 she works as Prime En-
docrinologist at Euromedik General Hospital, Belgrade where,
she organized endocrinology service and several symposiums
in Belgrade and Rome where she was a speaker. She spoke at
several international congresses. She has published 23 papers
in reputed journals. She is a member of European and Italian
Endocrinology Society.
Nevena Ilic et al., Int J Anesth Pain Med 2019, Volume 5
DOI: 10.21767/2471-982X-C1-005