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Volume 3, Issue 4 (Suppl)
J Clin Exp Orthop
ISSN:2471-8416
Osteoporosis and Arthroplasty 2017
December 04-05, 2017
&
11
th
International Conference on
Joint Event
OSTEOPOROSIS, ARTHRITIS & MUSCULOSKELETAL DISORDERS
December 04-05, 2017 | Madrid, Spain
10
th
INTERNATIONAL CONFERENCE ON ARTHROPLASTY
Eman M Alissa et al., J Clin Exp Orthop 2017, 3:4(Suppl)
DOI: 10.4172/2471-8416-C1-003
Dietary antioxidants and risk of clinical knee osteoarthritis: Is there a protective role?
Eman M Alissa, Layla S Alzughaibi, Zuhair M Marzouki
and
Mohammed-Salleh M Ardawi
King Abdulaziz University, Saudi Arabia
Background:
Osteoarthritis (OA) is a degenerative disease of the joints that occurs commonly in female older population with the
knee being the most frequently affected site of all joints. Excess oxidative damage have been associated with the pathogenesis of
OA. Therefore, we aimed to explore the associations between intake levels of dietary antioxidants micronutrients and radiographic
severity of osteoarthritis in females with and without clinical knee OA.
Method:
One hundred female participants, aged above 40 years, with symptomatic primary knee OA were matched for age with
100 apparently healthy females in a case-control study. The study subjects were consecutively recruited from the Orthopaedics
Department, Faculty of Medicine, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. All subjects underwent weight-bearing
bilateral anteroposterior radiography of the knee. All radiographs were graded using the Kellgren-Lawrence grading system (grades
0-4). The symptomatic severity of OAwas assessed by the validated version of Western Ontario andMcMaster Universities (WOMAC)
index. Dietary intake was assessed using a pre-validated semi-quantitative food frequency questionnaire.
Results:
Patients with knee OA had significantly lower intake levels of dietary vitamin C (p<0.01), vitamin A, zinc, copper and
selenium (p<0.0001 in all) than their control counterparts. Additionally, WOMAC index is significantly and negatively associated
with intake levels of vitamin C, vitamin A, zinc, copper and selenium.
Conclusions:
These results indicate that dietary antioxidants micronutrients may have an important role in the progression of knee
OA. While our findings warrent futher confirmation, they highlight the potential of diet to modify the risk of osteoarthritis.
Biography
Eman M Alissa received her PhD in 2005 from the School of Biomedical and Molecular Sciences, University of Surrey, UK. Her thesis was involving micronutrient
status in cardiovascular diseases. In 2015, she became the Head of the Elemental Spectroscopy Unit, in King Fahad Medical Research Center, King Abdulaziz
University, Saudi Arabia. She is presently a Professor at the Clinical Biochemistry Department, Faculty of Medicine, KAU. Her research interests are: Trace
elements and antioxidant vitamins status in chronic diseases, epidemiology, and aging and chronic diseases. She has published around 60 articles and attended
several conferences where she presented her research work results.
Em_alissa@yahoo.com