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Volume 3, Issue 4 (Suppl)
J Clin Exp Orthop
ISSN:2471-8416
Osteoporosis and Arthroplasty 2017
December 04-05, 2017
Page 15
Notes:
&
11
th
International Conference on
Joint Event
OSTEOPOROSIS, ARTHRITIS & MUSCULOSKELETAL DISORDERS
December 04-05, 2017 | Madrid, Spain
10
th
INTERNATIONAL CONFERENCE ON ARTHROPLASTY
Ying Gu, J Clin Exp Orthop 2017, 3:4(Suppl)
DOI: 10.4172/2471-8416-C1-001
MMP inhibitors as novel therapeutics for osteoporosis
W
e have developed novel non-antibiotic tetracycline (TC) formulations (Sub-antimicrobial Dose Doxycycline; SDD)
and compounds (Chemically Modified Tetracyclines; CMTs) as matrix metalloproteinase inhibitors (MMPI). We and
others demonstrated that they also inhibit osteoclast-mediated bone resorption associated with various conditions such as
post-menopausal (PM) osteoporosis and diabetes-mediated osteoporosis in tissue culture, in animal models and in human
clinical trials. In the ovariectomized rats, non-antimicrobial TCs were found to increase bone formation, as well as inhibit
bone resorption, as mechanisms which “normalize” bone density. In a more recent NIH-supported study, we carried out a
double-blind placebo-controlled clinical trial on 126 PMwomen exhibiting both periodontal (alveolar) bone loss and systemic
bone loss (osteopenia). The 2-year regimen of SDD adjunctive to periodontal maintenance therapy not only significantly
reduced: (1) the bone resorption marker, ICTP, and MMPs, in periodontal lesions, and (2) the progressive loss of alveolar
bone; but also reduced the bone resorption markers, ICTP and CTX systemically in the serum samples from these patients.
We propose that SDD reduces the risk of conversion of mild systemic bone loss (osteopenia) into the more severe form of
bone deficiency disease, osteoporosis. Currently, we are developing new therapeutics derived from natural products (i.e., the
chemically modified curcumins) as MMP-, and bone-resorption-inhibitors to treat chronic diseases such as osteoporosis and
osteoarthritis.
Biography
Ying Gu has received her DDS and Ph.D degrees and resident studies from Stony Brook University School of Dental Medicine. She is currently an Associate Professor
in the Department of General Dentistry, Stony Brook University. She has published book chapters and papers in reputed journals and serving as the reviewer of multiple
journals.
Ying.gu@stonybrook.eduYing Gu
Stony Brook University, USA