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Orthopedics and Osteoporosis 2018
N o v e m b e r 2 9 - 3 0 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Page 57
Journal of Clinical & Experimental Orthopaedics
ISSN: 2471-8416
E u r o p e a n C o n f e r e n c e o n
Orthopedics and
Osteoporosis
Background & Objectives:
Primary leiomyosarcoma of bone is a rare and a diagnostically challenging tumor entity. To our
knowledge, around 90 cases have been described with the largest by Antonescu etal. in 1997. We have reviewed our experience
in treating patients with primary leiomyosarcoma of bone between 2010 and 2017, trying to identify prognostic indicators and
outcomes.
Materials & Methods:
We retrospectively reviewed cases of six patients from our database, who were diagnosed as primary
leiomyosarcoma of bone from 2010 to 2017.
Results:
Over a 7-year period, we identified six cases that fulfilled the diagnostic criteria in five men and one female, with age
ranging from 19 to 66 years (mean-37.66 years). No case had any metastasis at presentation and neither of them had any
lymph nodal involvement. All cases underwent limb salvage surgery (five megaprosthesis, one intercalary resection and fibular
grafting). On final histological evaluation, three cases were grade 3 and three more were grade 2 as per FNLCC grading system.
Three patients were given adjuvant chemotherapy and two were given adjuvant radiotherapy. On follow up, none of the patient had
local recurrence but one had local infection which was managed conservatively with antibiotics and debridement. Two patients
developed distant metastasis both were of grade 3 histology. Mean event free survival was 21.16 months and mean overall
survival was 26.83 months.
Conclusion:
Primary leiomyosarcomas of bone are aggressive tumours which should be treated just like osteosarcoma but,
according to our experience. Primary leiomyosarcomas has a slightly better prognosis than patients with osteosarcoma. Surgical
resection remains the mainstay of management of LMS of bone. The role of adjuvant chemotherapy or radiotherapy requires
further evaluation.
drrohela@gmail.comOutcome of primary leiomyosarcoma of bone: a
single center experience
Himanshu Rohela
1
and Manish Pruthi
2
1
Seoul National University Hospital, South Korea
2
Rajiv Gandhi Cancer Hospital, India
J Clin Exp Orthop 2018, Volume: 4
DOI: 10.4172/2471-8416-C1-006