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Page 31
J Obes Eat Disord, 2017
ISSN: 2471-8203
August 23-24, 2017 | Toronto, Canada
allied
academies
INTERNATIONAL OBESITY, BARIATRIC AND
METABOLIC SURGERY SUMMIT AND EXPO
Notes:
Moise Bendayan
University of Montreal, Canada
Oral administration of leptin for the control of food intake and weight
management
L
eptin plays fundamental roles regulating appetite and
energy expenditure. Originally discovered as an adipokine,
it is also secreted by the gastric chief cells in an exocrine
regulated fashion. To overcome the harsh conditions of
the gastric juice it is complexed to a chaperon, the soluble
isoform of its receptor. The released leptin-leptin receptor
complex is channeled towards the intestinal lumen. Leptin is
then internalized by the duodenal enterocytes, transcytosed
and released towards circulation to reach target cells. The
physiological presence of leptin in the gastric juice led us to
put forward the proposal of an oral administration of leptin.
Oral leptin administered in an appropriate vehicle that
protects from early degradation by gastric and pancreatic
juices and promotes internalization by the intestinal cells, led
to its rapid appearance in circulation. Once administered to
normal and obese mice, oral leptin decreased food intake by
60% and significantly reduced body weight. The effects were
proportional to the administered amounts. By adjusting
these, we were able to reduce and stabilize body weight
in ob/ob obese mice for long periods of time. Studies with
dogs using an oral tablet containing leptin with the different
components that protect and promote leptin internalization,
has shown its efficiency in reducing food intake. Further
studies demonstrated that oral leptin stimulated brown
adipose tissue. It activates UCP1 and other mitochondrial
enzymes for lipid oxidation, lipolysis and decreases in fat
synthesis, leading to rapid reduction of body weight and
adiposity. Taken together these results demonstrate that
oral leptin reaches blood circulation and target cells very
efficiently. Besides acting as a satiety hormone reducing
appetite and decreasing food intake, oral leptin triggers
lipolysis for the overall major loss of body weight.
Speaker Biography
Moise Bendayan Full Professor Department of Pathology & Cell Biology, Faculty of
Medicine Université de Montréal, Montreal Quenbec Canada 1976: Ph.D. Anatomy
University of Montreal (Drs Rasio & Sandborn) 1976-1979 Post-doctoral training,
Département de Morphologie Université de Genève (Dr Orci ) 1981-1982 Institut
de la recherche sur le cancer Villejuif France (Dr Puvion) 1987 and 2006 Sabbatical
at the Diabetes Unit, Hadassah Hospital Hebrew University Jerusalem, 1979-Assistant
Professor University of Montreal 1988- now Full Professor 1990-98 Chair Department
of Anatomy-Cell biology Membre du Montreal Diabetes Center Research grants from:
CRM, IRSC, FRSQ, Heart Fondation, Juvenile Diabetes Foundation, NIH, Diabete Quebec
and others Average 150,000-200,000$/year + millions in equipment Publications by
December 2016. 21 book chapters 290 original articles in peer reviewed journals
(Nature, Science, Journal of Cell Science) 291 Congress Abstracts. Administration
:Chairman of the Department Member of many Scientific Associations among which
: President of the American Histochemical Society , Vice President of the Canadian
Anatomists ,President and Member of the CIHR, FRSQ. Diabete Quebec…research
committees Research on Endocrinology, Diabetes, Obesity, Cell and Molecular Biology
since 1972
e:
moise.bendayan@umontreal.caMoise Bendayan, J Obes Eat Disord, 3:2
DOI: 10.21767/2471-8203-C1-001