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Volume 4
Journal of Pediatric Care
ISSN: 2471-805X
Page 28
Notes:
May 07-08, 2018 Frankfurt, Germany
&
JOINT EVENT
3
rd
International Conference on
Pediatrics and Pediatric Surgery
22
nd
Edition of International Conference on
Neonatology and Perinatology
The effect of prematurity on caffeine metabolism in preterm infants
C
affeine is a methylxanthine and a first-line pharmacotherapy agent in apnea of prematurity. Caffeine is preferable to
theophylline because of its fewer adverse effects and a wider therapeutic window. In general, measurement of serum
caffeine concentration is not required in preterm neonates because a majority of them can maintain therapeutic levels. We
present the first reported case of a preterm neonate, whose serum caffeine concentration exceeded therapeutic levels, resulting
in rhabdomyolysis. Caffeine is metabolized by the hepatic cytochrome P-450 monooxygenase pathway, but its activity is lower
in premature infants than in adults.Therefore, more than 85% of the administered dose of caffeine is recovered unchanged in the
urine of an infant during the 1st month of life. Since we are interested in caffeine metabolism in preterm infants, we measured
serum caffeine concentration in 24 preterm infants, sequentially. We addressed the relationship between caffeine metabolism
and postnatal age or postmenstrual age. Our aim is to elucidate the development and systems of caffeine metabolism according
to their growth. Although caffeine has been used in many NICUs, I would like to discuss caffeine metabolism in preterm
infants.
Biography
Taketoshi Yoshida graduated from Toyama Medical and Pharmaceutical University and got medical license in 1994. He has completed his PhD in 2002 from Toyama
University. He has performed genetic research work at Institute for Virus Research, Kyoto University and German Rheumatism Research Centre, Berlin. He is the Director
of Maternal and Perinatal Center, Toyama University Hospital. He focuses on the neonatal basic and translational research at present.
ytake@med.u-toyama.ac.jpTaketoshi Yoshida
Toyama University Hospital, Japan
Taketoshi Yoshida, J Pediatr Care, Volume 4
DOI: 10.21767/2471-805X-C2-007