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Volume 4, Issue 2
American Journal of Ethnomedicine
ISSN 2348-9502
Natural Products Congress & World Pharma Congress 2017
October 16-18, 2017
Page 38
Notes:
3
rd
World Congress on
NATURAL PRODUCTS CHEMISTRY AND RESEARCH
&
12
th
WORLD PHARMA CONGRESS
October 16-18, 2017 Budapest, Hungary
Xiao-Ling Shen, American Journal of Ethnomedicine, 4:2
DOI: 10.21767/2348-9502-C1-001
Cajanonic acid A from
Cajanus cajan
regulates lipid metabolism
in vitro
and
in vivo
P
revention of obesity and related lipid metabolic disorder is an important strategy in treatment and prevention of metabolic
diseases such as diabetes, hyperlipidemia and hypertension. Cajanolic Acid A (CAA) is a stilbene isolated from the leaves
of
Cajanus cajan
(L.) Mills. exhibiting PTP1B inhibitory activity in our previous screening. Activity of CAA on lipogenesis and
lipolysis was also investigated. In our study, CAA inhibited the differentiation of 3T3-L1 preadipocyte into mature adipocyte,
at the same time it inhibited TG accumulation within mature 3T3-L1 adiocyte and reduced the release of glycerol and Free
Fatty Acids (FFA) by the cell. Further study revealed that CAA inhibits adipocyte differentiation and TG synthesis via down
regulation of PPARγ and C/EBPα which are key transcriptional factors in adipocyte differentiation, and other adipogenic
genes (
ACC, FAS, LPL
, etc.), and inhibits mature adipocyte to release glycerol and FFA by down-regulating genes related to
lipolysis (
HSL
and
ATGL
), and up-regulating genes (
ACOX & CPT-1
) crucial to fatty acid oxidation. Ability of CAA to regulate
lipid metabolism was confirmed in Zucker fatty rats, treatment with CAA achieved dose-dependent reduction in serum levels
of TC and inhibition in increase of serum TG. In T2DM SD rats with hyperlipidemia, CAA not only inhibited the increase in
blood glucose, but also significantly reduced the serum levels of TG, TC and LDL-C, and showed protective effect on organ
damage brought by hyperglycemia and hyperlipidemia. In summary, CAA improved lipid metabolism both
in vitro
and
in vivo
,
showing potential in treatment of hyperlipidemia.
Biography
Xiao-Ling Shen PhD is a Professor at the Laboratory of Herbal Drug Discovery, Tropical Medicine Institute, Guangzhou University of Chinese Medicine. Her research focus
is Chinese herbal medicines with anti-obese, anti-diabetic or anti-tumor efficacy.
xshen2@gzucm.edu.cnXiao-Ling Shen
Guangzhou University of Chinese Medicine, China