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E u r o S c i C o n C o n f e r e n c e o n
Nanotechnology &
Smart Materials
Nano Research & Applications
ISSN 2471-9838
O c t o b e r 0 4 - 0 6 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Nanotechnology & Smart Materials 2018
Page 23
D
ifferent approaches to develop graphene based sensors with possible
applications for ultra-sensitive detection and quantification of molecules
and biomarkers as well as for optical imaging of any 2D or quasi 2D materials
are presented. On one hand, we focus on enhancing the analyte Raman signal
by optimizing and combining different amplification mechanisms. Raman
spectroscopy is a non-destructive easy to use and specific technique but with low
sensitivity. Heterostructures of highly reflecting aluminum and adequate dielectric
films have been designed and fabricated to maximize the interference enhanced
Raman scattering effect (IERS). Graphene is used as an excellent platform for
organic and biomolecules deposition. The combined amplification with that
related to localized plasmons of metallic nanoparticles (SERS) is demonstrated. In
the same direction, a very interesting IERS amplification platform is that provided
by adequately designed ordered porous alumina structures. CVD graphene
is transferred on top of the pores so that a continuous flat surface allows the
deposition of the analyte. These IERS platforms also provide amplification of
fluorescence signals and increase significantly the quality of the optical images
for sufficiently thin inorganic or organic samples. Another approach is based on
the covalent functionalization of graphene by adding carboxyl acid groups which
allow successive binding with different biologically active molecules for antigen
sensing applications. We present a new approach for in-situ specific surface
functionalization of graphene which differ from the commonly used graphene
oxide derivedmaterials. With thismethod, it is possible to obtain highly conductive
COOH functionalized either monolayer or few-layer graphene films. The relative
concentrations of defects and functional groups are optimized and the electronic
transport characteristics (sheet resistance and mobility) are very adequate for
sensing. The bio-molecules detection is carried out by fluorescence images
Biography
Alicia de Andrés received her PhD in Physics from the Autono-
mous University of Madrid. Since 2008, she is Research Profes-
sor at the Materials Science Institute in Madrid. She is the Lead-
er of the Graphene based hybrid materials group and head of
the Optical Spectroscopies Laboratory. She has authored over
160 WOS publications and leaded and participated in projects
funded by national, regional and European agencies as well as
industrial companies. Her research has focused on the devel-
opment and study of materials with applications in spintronics
and optoelectronics. At present, her interest is developing in
graphene based hybrid materials with optimal synergy of or-
ganic semiconductors, inorganic nanoparticles and graphene
properties for applications as transparent electrodes and as
nanostructured active layers in PVs, LEDs, sensors and SERS
imaging, materials for lighting and photovoltaics based on rare
earth doped nanoparticles and metal organic frameworks as
well as metal-organic perovskites.
ada@icmm.csic.esGraphene based platforms for biosensing and
enhanced optical imaging
Alicia de Andres
1
, S Cortijo
1
, M Aguilar-
Pujol
1
, L Alvarez-Fraga
1
, L F Marsal
2
, M Vila
3
,
R Ramirez-Jimenez
1, 4
and C Prieto
1
1
Instituto de Ciencia de Materiales de Madrid-CSIC, Spain
2
Rovira I Virgili University, Spain
3
University of Aveiro, Portugal
4
Universidad Carlos III de Madrid (UC3M), Spain
Alicia de Andres et al., Nano Res Appl Volume:4
DOI: 10.21767/2471-9838-C6-023