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Der Pharmacia Sinica
ISSN: 0976-8688
Eurosc i con Conference on
Medicinal Chemistry
and Biosimilars
M a r c h 2 5 - 2 6 , 2 0 1 9
B u d a p e s t , H u n g a r y
Medicinal Chemistry & Biosimilars 2019
S
eries of novel β and meso 5,10,15,20-tetraphenylporphyrins Schiff bases were synthesized via Schiff base condensation
reaction, the β -linked 5,10,15,20-tetraphenylporphyrins Schiff bases were synthesized starting from β-formyl
5,10,15,20-tetraphenylporphyrin and amino alkanes in moderate yields. While meso-linked 5,10,15,20-tetraphenylporphyrins
Schiff bases were synthesized via refluxing 5-(4-aminophenyl)-10,15,20-triphenylporphyrin and different aromatic benzal dehyde.
The two newly synthesized series of porphyrin Schiff bases were compared and characterized on the basis of their chemical
properties, stability and spectral data. The properties of these new β -linked 5,10,15,20-tetraphenylporphyrin Schiff bases and
meso linked 5,10,15,20-tetraphenylporphyrin were investigated and were observed with different stability. The rotational stability
of these β-linked and meso-linked 5,10,15,20-tetraphenylporphyrin Schiff bases deduced by 1HNMR, was calculated and all
newly synthesized compounds were further characterized by UV-VIS spectroscopy and high resolution mass spectroscopy. They
were further tested for their potential analgesic and anti-inflammatory activities in acetic acid induced writhing test in mice and
carrageenan induced paw edema in rats. The compounds were also evaluated for antibacterial activity in disc diffusion method.
Compounds 1a 1b 1c 1d showed significant analgesic and anti-inflammatory activity at 10 and 30 mg/kg (b.w), comparable to
the standard reference drugs. Furthermore, all the tested compounds possessed significant anti-bacterial activity against both
gram positive and gram negative bacteria. The analgesic, anti-inflammatory and anti-bacterial activities of the tested compounds
were found comparable to reference drugs. These compounds can serve as precursors for the development of clinically useful
analgesics, anti-inflammatory and anti-bacterial agents.
mianguls696@uswat.edu.pkSynthesis and evaluation of analgesic, anti-
inflammatory and anti-bacterial activity of
beta and meso 5,10,15,20-tetraphenylporphyrins
Schiff bases and their metal complexes
Mian Gul Sayed
1
, M Naveed Omer
2
and Ihsanullah
1
1
University of Swat, Pakistan
2
University of Malakand, Pakistan
Der Pharmacia Sinica 2019, Volume:10
DOI: 10.21767/0976-8688-C1-003