enzymology-2018-keynote

E u r o S c i C o n C o n g r e s s o n

Enzymology and

Molecular Biology

Insights in Enzyme Research

ISSN: 2573-4466

A u g u s t 1 3 - 1 4 , 2 0 1 8

P a r i s , F r a n c e

Enzymology 2018

Page 18

Winfried Hinrichs, Insights Enzyme Res 2018, Volume 2

DOI: 10.21767/2573-4466-C1-001

his review will give a short overview on structural biology of tetracyclines.

The group of tetracycline are one of the “big four” of antibiotic compounds.

Tetracyclines block the bacterial protein synthesis by binding to the ribosomal 30S

subunit. Crystal structure analyses of proteins that mediate resistance against the

drug belong to a widespread efflux mechanism (Tet repressor controlled) and a

chemical inactivation by a flavinmonooxygenase (TetX). Non-antibiotic properties

are also well known: tetracyclines interfere with inflammatory mechanisms

by inhibiting Phospholipase A2. All these tetracycline binding proteins are

characterized at atomic resolution. The tetracycline can act as a regulatory

compound but is also a substrate or inhibitor for enzymatic mechanisms. The

conclusion is that tetracyclines are an example for side effects of drugs that are

more interesting than the obvious mode of action.

Biography

Winfried Hinrichs studied Chemistry and completed his PhD

in 1983 at the University of Hamburg followed by Postdoctoral

studies at the Rijksuniversiteit Leiden in 1984/5. He joined the

group of Wolfram Saenger at the Free University of Berlin and

expanded his crystallographic expertise to bio-crystallography

(1986-1999). After a sabbatical in Strasbourg (IGBMC, Dino

Moras) in 1998/99, he became a Full Professor in Biochemistry

focused on Structural Biology at the University Of Greifswald,

Germany. He was the Director of the Institute Of Biochemistry

in 2008-2014 and retired in 2016. He has published about 120

papers in reputed journals and is serving as Topical Editor for

Biochemistry of Chemtexts

Protein binding to Tetracyclines:

Inhibitor, Regulator, Substrate

Winfried Hinrichs

University of Greifswald, Germany