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Volume 3, Issue 2
ISSN: 2470-9905
Crystallography 2017
October 16-17, 2017
2
nd
International Conference on
October 16-17, 2017 | Chicago, USA
Applied Crystallography
X-ray diffraction reveals the mechanical load tolerance of mammalian nerve, muscle and tendon in
traumatically induced injury and the vertebrate identity of fossilized T-rex bone
T
hose living with traumatically induced injuries, including but not limited to, Traumatic Brain Injury (TBI), face an elevated
risk for developing chronic health issues including Alzheimer’s disease (AD) or AD-like dementia and depression. One of
the most serious impediments to the study of traumatic injury is the lack of meaningful primary mechanical damage criteria at
the molecular level. This study addresses this, through the use of novel imaging technologies such as a newly developed X-ray
Diffraction (XRD) scanning methodology, applied to systemically loaded animal models of both brain and connective tissue
injury and accompanied by conventional microscopy for cross-correlation of observations. Interestingly, this same technique
reveals the state and status of soft tissue preserved in T-rex fossilized bone.
Biography
Joseph Orgel is a British American Scientist based at the Illinois Institute of Technology with past and present appointments in Biology, Physics and Biomedical
Engineering and Applied Health Sciences at UIC as Visiting Faculty. His research interests are concerned with fundamental structural biochemistry problems that
have direct links to the understanding and treatment of disease. He leads investigations of brain pathological diseases such as Alzheimer’s and Traumatic Brain
Injury in collaboration with the US Army and connective tissue conditions including heart disease and arthritis at the National Institutes of Health Biotechnology Re-
search Resource, BioCAT, as Associate Director. He is an awardee of the United States National Science Foundation's CAREER Award. He has been Biochemistry
Section Editor of the Public Library of Science Journal, PloS ONE since 2008 and joined the board of Directors of the National Museum of Health and Medicine
(Chicago) in December of 2012.
orgel@iit.eduJoseph Orgel
Illinois Institute of Technology, USA
Joseph Orgel, Struct Chem Crystallogr Commun, 3:2
DOI: 10.21767/2470-9905-C1-001
Figure-1: Molecular representation of connective tissue structure