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E u r o S c i C o n C o n f e r e n c e o n
Chemistry
2018
Journal of Organic & Inorganic Chemistry
ISSN 2472-1123
F e b r u a r y 1 9 - 2 0 , 2 0 1 8
P a r i s , F r a n c e
Chemistry 2018
Page 12
N
atural polysaccharides such as cellulose, starch, and chitin are widely
distributed in nature and thus considered as the very important biomass
resources. They can also be expected as biomedical materials comparable to
proteins, but researches on their practical applications have been still devoted
even in recent years. Therefore, the efficient methods for synthesis of functional
polysaccharides have attracted much attention to provide new environmentally
benign materials. Enzymatic polymerization approach has been identified as
a powerful tool to provide polysaccharides with well-defied structure because
it is progressed with highly controlled manner in regio and stereo-specificities.
Phosphorylase-catalyzed enzymatic polymerization is one of the practically used
approaches to synthesize well-defined polysaccharides, which is performed using
α-D-glucose 1-phosphate (Glc-1-P) as a monomer and maltooligosaccharide as
a primer to produce α(1
4)-glucan, that is amylose. The author has reported
the synthesis of amylose-grafted polymeric materials by chemoenzymatic
approach, which is a combinedmethod of the phosphorylase-catalyzed enzymatic
polymerization with appropriate chemical reactions. The author has also found
that by means of the phosphorylase-catalyzed enzymatic polymerization using
analog substrates as monomers, well-defined polysaccharides with functional
groups, such as amino group, are efficiently synthesized. Furthermore, amphoteric
polysaccharideshavebeensynthesizedbythephosphorylase-catalyzedenzymatic
polymerization. The products showed specific inherent isoelectric points (pIs) and
formed large aggregates in water at pH = pI, whereas disassembled at pH shifted
from pI. These properties of the present materials are similar as those of proteins.
Biography
Jun-Ichi Kadokawa has completed his PhD in 1992. He
then joined Yamagata University as a Research Associate.
From 1996 to 1997, he worked as a Visiting Scientist at the
Max-Planck-Institute for Polymer Research in Germany. In
1999, he became an Associate Professor at Yamagata Univer-
sity and moved to Tohoku University in 2002. He was appointed
as a Professor of Kagoshima University in 2004. His research
interests focus on polysaccharide materials. He received the
Award for Encouragement of Research in Polymer Science in
1997 and the Cellulose Society of Japan Award in 2009. He has
published more than 200 papers in academic journals.
kadokawa@eng.kagoshima-u.ac.jpPrecision synthesis of functional
polysaccharides by enzymatic
polymerization
Jun-Ichi Kadokawa
Kagoshima University, Japan
Jun-Ichi Kadokawa, J Org Inorg Chem 2018, Volume: 4
DOI: 10.21767/2472-1123-C1-001