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August 17-18, 2017 | Toronto, Canada
ANNUAL BIOTECHNOLOGY CONGRESS
alliedacademies
Ann Biol Sci, 2017
ISSN: 2348-1927
Ganapathy Sivakumar
University of Houston, USA
Biomanufacturing of biorhizome
G loriosa superba seed is the most important traditional
plant-based colchicine source for pharmaceutical
industry. Colchicine prevents microtubules assembly
and thereby suppresses cancer cell division by inhibiting
mitosis as well as successfully used in gout medicine. My
lab established the biorhizome platform to biomanufacture
natural isomer colchicine, which is a new biotech concept
in industrial biotechnology. However, limited emphasis has
been placed on identifying colchicine biosynthetic pathway
genes in G. superba biorhizome. In addition, understanding
the dynamics of biorhizome developmental events is
essential to improve the colchicine biomanufacturing. The
presentation will cover current knowledge of colchicine
biosynthetic pathway elucidation and biorhizome-based
colchicine biomanufacturing.
Speaker Biography
Ganapathy Sivakumar has extensively studied the plant-based small molecules path-
way biochemistry, synthetic biotechnology and metabolic and bioprocess engineering.
His research is primarily focused on Biomanufacturing and Biotech implications of Bio-
pharmaceuticals. He is internationally recognized in the field of Biopharmaceuticals
and a pioneer in Biomanufacturing of biorhizome-based colchicine. He has over 45
publications. He is also on the editorial board of several journals. He serves as an ex-
pert of grant proposals as well as numerous scientific journals. His laboratory focuses
on metabolic and bioprocess engineering of colchicine pathway and developing poten-
tial anticancer medicine.
e:
Ganapathy Sivakumar, Ann Biol Sci, 2017, 5:3
DOI: 10.21767/2348-1927-C1-001