alzheimers-dementia-2018-scientifictracks

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Page 24
December 06-07 , 2018
Amsterdam, Nether l ands
Journal of Neuropsychiatry
ISSN: 2471-8548 Alzheimer’s and Dementia 2018
1 3 t h W o r l d c o n g r e s s o n
Alzheimer’s and Dementia
Background and aims: Carcinoembryonic antigen (CEA) is a tumour marker
associated with various malignancies and is now being investigated as a
biomarker for early diagnosis of acute coronary syndromes. Its levels may rise
even prior to the elevation of established markers of myocardial necrosis.
Methods: Two groups of subjects with unstable angina and healthy controls with
45 males between 40 to 60 years of age in each group were recruited. Serum
CEA concentrations and quantitative troponin-I levels were measured by double
sandwich ELISA method in all the subjects and the correlation between the two
were observed.
Results: Mean serum CEA concentrations were 5.830±0.284 and 1.676±0.284
ng/ml respectively in unstable angina and control groups and the difference
was statistically highly significant (p<0.001). Mean serum troponin-I levels were
0.426±0.073 and 0.449±0.073 ng/ml in unstable angina and control groups
respectively (p=0.832). No significant correlation was found between serum
CEA and CPK-MB levels in unstable angina (UA) patients (p=0.061). Also, no
significant correlation was found between serum CEA and troponin-I levels in UA
patients (p=0.655) indicating CEA levels rise independently, and prior to elevation
of troponin-I. Statistically significant correlations were found between CEA and
BMI, waist circumference, waist hip ratio, systolic and diastolic blood pressures,
total leucocyte count, random blood sugar, total cholesterol, HDL and LDL.
Conclusions: CEA is a sensitive biomarker for diagnosis of unstable angina in
which the traditional cardiac biomarkers such as CPK-MB and cardiac troponins
are not raised. It may have a significant role in diagnosis of unstable angina
patients who present with atypical manifestations.
Biography
Gajender Singh Ranga has completed his MBBS at the age
of 23years from MD University Rohtak and completed his
MD from prestigious All India institute of medical sciences,
Delhi-110095. He is consultant of Medicine for last 20
years and currently acting as Director Professor in Dept
of Medicine at Guru Teg Bahadur Hospital and University
college of Medical Sciences, Delhi-110095, India. He has
published more than 25 papers in reputed journals and has
been serving as an editorial board member of Journal of
advanced research in Medicine.
A study of carcinoembryonic antigen in patients with unstable
angina and its correlation with quantitative Troponin-I
Gajender Singh Ranga, Rakshith R Bharadwaj, S Giri and Suman
Bala Sharma
Guru Teg Bahadur Hospital and University College of Medical Sciences, India
Gajender Singh Ranga et al., J Neurol Neurosci 2018, Volume: 2
DOI: 10.21767/2471-8548-C1-002