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Advanced Dental Care 2018 Dentistry and Craniofacial Research
ISSN: 2576-392X Page 17
October 08-09, 2018
Moscow, Russia
26th International Conference on
Advanced Dental Care
For this split mouth randomized study nine adult New
Zealand rabbits were considered. The control side of the
mandible was augmented with autograft block harvested
from the iliac crest, while xenograft was used on the test
side (Heket Biomaterials, Vicenza, Italy). Dimensions of the
graft were 10 mm diameter x 3 mm height. Recipient bed
sites were equally perforated. Grafts were fixed with 1.5x10
mm titanium positional screws and covered with a collagen
membrane (Heket Biomaterials, Vicenza, Italy). Three animals
were sacrificed at 07, 20 and 60 days respectively. Biopsies
were taken for histological analysis. Paraffin sections were
stained with Hematoxylin-Eosin and Masson´s Trichrome.
At 07 days, xenografts showed a scaffold with empty
lacunae, while autografts presented a complex pristine bone
architecture including osteocytes and bone marrow. Blood clot
and inflammatory cells infiltration were observed arising from
recipient bed perforations in both groups. At 20 days, a sparse
immature and non-organized new bone formation was found
for xenograft, while autograft presented an intense woven bone
formation. Osteoblast bone matrix deposition and osteoclast
resorption activity was also observed as part of remodelling
bone process. For both autograft and xenograft groups, a
clear delimitation between graft and recipient bed was still
noticed. However, at this time, graft union was more evident for
autograft. New bone was found forming mostly from recipient
bed perforations and close to the membrane for both groups.
At 60 days, xenograft showed a higher level of resorption when
compared to autografts. Graft union became bridged by well-
organized bone for both groups. Considering the limitations of
the present study, it can be suggested that autograft provides a
better bone formation and maintenance overtime.
Biography
Samuel P Xavier (Oral and Maxillofacial Specialist since 1995) has complet-
ed his PhD from Sao Paulo State University, Brazil and Postdoctoral studies
from University of Freiburg, Germany (2008-2009) respectively. He is cur-
rently working as an Associate Professor in the Department of Oral Maxillo-
facial Surgery and Periodontology, Faculty of Dentistry at University of Sao
Paulo. He has published more than 50 papers in reputed journals and is a
Member of the Board of the Oral and Maxillofacial Surgeons at the Hospital
of the Medical Faculty of University of Sao Paulo since 1997.
Comparative analysis of autogenous vs.
xenogenous bone grafts in rabbit mandible:
Preliminary histological results
Samuel P Xavier1, Erick R Silva 1, Dimitrius L Pitol1, Lucas B Chaves1, Vitor F Bal-
an1 and Daniele Botticelli2
1University of Sao Paulo, Brazil
2ARDEC Academy, Italy
Samuel P Xavier et al., Dent Craniofac Res 2018, Volume 3
DOI: 10.21767/2576-392X-C4-011